Plasma apolipoproteins in Tangier disease, as studied with two- dimensional electrophoresis

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 33; no. 1; pp. 120 - 122
• Main Authors: Visvikis, S, Dumon, MF, Steinmetz, J, Manabe, T, Galteau, MM, Clerc, M, Siest, G
• Format: Journal Article
• Language: English
• Published: Washington, DC Am Assoc Clin Chem 01.01.1987; American Association for Clinical Chemistry
• Subjects: Adult; Apolipoprotein A-I; Apolipoprotein C-III; Apolipoproteins - blood; Apolipoproteins A - blood; Apolipoproteins C - blood; Biological and medical sciences; Child; Disorders of blood lipids. Hyperlipoproteinemia; Electrophoresis - methods; Humans; Hypolipoproteinemias - blood; Isoelectric Focusing; Male; Medical sciences; Metabolic diseases; Tangier Disease - blood; Tangier Disease - genetics; Human; Exploration; Lipids; Metabolic diseases; Apolipoproteins; Hyperalphalipoproteinemia; Genetic disease

Tangier disease is characterized by a deficiency of high-density lipoproteins and of their major protein constituent, apolipoprotein (apo) A-I. We used high-resolution two-dimensional electrophoresis to examine the principal plasma apolipoproteins (A-I, A-II, A-IV, E, C-II, and C-III) of three perso...