Thermoresponsive gating membranes embedded with liquid crystal(s) for pulsatile transdermal drug delivery: An overview and perspectives

• Published in: Journal of controlled release Vol. 319; pp. 450 - 474
• Main Author: Lin, Shan-Yang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.03.2020
• Subjects: Chronotherapy; Circadian rhythm; drug delivery systems; drug development; humans; Liquid crystal; liquid crystals; Membrane; On-off; permeability; Permeation; polymers; Pulsatile drug delivery systems (PDDSs); temperature; Thermoresponsive; topical application; Transdermal; transdermal application; water solubility; Pulsatile drug delivery systems (PDDSs); On-off; Liquid crystal; Permeation; Membrane; Chronotherapy; Transdermal; Circadian rhythm; Thermoresponsive

Due to the circadian rhythm regulation of almost every biological process in the human body, physiological and biochemical conditions vary considerably over the course of a 24-h period. Thus, optimal drug delivery and therapy should be effectively controlled to achieve the desired therapeutic plasma...