Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma

• Published in: Cancers Vol. 13; no. 22; p. 5623
• Main Authors: Chen, Ting-Wen, Chang, Kai-Ping, Cheng, Chun-Chia, Chen, Cheng-Yi, Hong, Shu-Wen, Sie, Zong-Lin, Cheng, Hsing-Wen, Yen, Wei-Chen, Huang, Yenlin, Liu, Shu-Chen, Wang, Chun-I
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.11.2021; MDPI
• Subjects: Antibiotics; Apoptosis; Bioinformatics; Cancer therapies; Cell cycle; Datasets; Deoxyribonucleic acid; DNA; DNA damage; Genes; Genomics; Medical prognosis; Oral carcinoma; Oral cavity; Oral squamous cell carcinoma; Patients; Prognosis; Radiation therapy; Radioresistance; Radiosensitivity; Therapeutic applications; Transcription; Tumors; United States > US

Radioresistance is one of the major factors that contributes to radiotherapy failure in oral cavity squamous cell carcinoma (OSCC). By comparing the prognostic values of 20,502 genes expressed in patients in The Cancer Genome Atlas (TCGA)-OSCC cohort with (n = 162) and without radiotherapy (n = 118)...