Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate

• Published in: The Journal of clinical investigation Vol. 91; no. 3; pp. 923 - 938
• Main Authors: Schwartz, C C, Zech, L A, VandenBroek, J M, Cooper, P S
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.03.1993
• Subjects: Bile - metabolism; Bile - secretion; Bile Acids and Salts - metabolism; Biliary Fistula - blood; Biliary Fistula - metabolism; Biliary Fistula - surgery; Biological and medical sciences; Carbon Radioisotopes; Cholecystectomy; Cholesterol - blood; Cholesterol - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Lipoproteins - blood; Liver - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Mevalonic Acid - metabolism; Models, Biological; Other diseases. Semiology; Radioisotope Dilution Technique; Tritium; Human; Biliary tract; Digestive diseases; Exploration; Fistula; Biliary tract disease; Metabolism; Cholesterol

Our aim was to identify and quantitate cholesterol pools and transport pathways in blood and liver. By studying bile fistula subjects, using several types of isotopic preparations, simultaneous labeling of separate cholesterol pools and sampling all components of blood and bile at frequent intervals...