Commitment of protein p53 and amyloid-beta peptide (Aβ) in aging of human cerebellum

• Published in: Folia neuropathologica Vol. 2; no. 2; pp. 161 - 167
• Main Authors: Maślińska, Danuta, Laure-Kamionowska, Milena, Szukiewicz, Dariusz, Maśliński, Sławomir, Księżopolska-Orłowska, Krystyna
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 01.01.2017
• Subjects: Aged; Aged, 80 and over; aging; Aging - metabolism; Aging - pathology; Amyloid beta-Protein Precursor - metabolism; amyloid-beta (Aβ) deposits; cerebellum; Cerebellum - metabolism; Cerebellum - pathology; Humans; Middle Aged; neurodegeneration; p53; Plaque, Amyloid - pathology; Tumor Suppressor Protein p53 - metabolism; neurodegeneration; amyloid-beta (Aβ) deposits; aging; cerebellum; p53

Protein p53 is known to induce the cell cycle arrest and apoptosis in response to a variety of cellular distress signals and DNA damage. A recent study has demonstrated that in blood cells of aging subjects, p53 may induce early pathological changes that precede the amyloidogenic cascade. However, i...