Histone modification patterns and epigenetic codes

The eukaryotic DNA is wrapped around histone octamers, which consist of four different histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally modified. The modification patterns constitute codes that regulate chromatin organisation and DNA utilization processes,...

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Published in	Biochimica et biophysica acta Vol. 1790; no. 9; pp. 863 - 868
Main Authors	Lennartsson, Andreas, Ekwall, Karl
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.09.2009
Subjects	Animals Cancer Cell Differentiation Chromatin Epigenesis, Genetic Epigenetic Histone code Histone modification Histones - metabolism Humans Neoplasms - etiology Histone modification Chromatin Epigenetic Cell differentiation Histone code Cancer
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Abstract	The eukaryotic DNA is wrapped around histone octamers, which consist of four different histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally modified. The modification patterns constitute codes that regulate chromatin organisation and DNA utilization processes, including transcription. Recent progress in technology development has made it possible to perform systematic genome-wide studies of histone modifications. This helps immensely in deciphering the histone codes and their biological influence. In this review, we discuss the histone modification patterns found in genome-wide studies in different biological models and how they influence cell differentiation and carcinogenesis.
AbstractList	The eukaryotic DNA is wrapped around histone octamers, which consist of four different histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally modified. The modification patterns constitute codes that regulate chromatin organisation and DNA utilization processes, including transcription. Recent progress in technology development has made it possible to perform systematic genome-wide studies of histone modifications. This helps immensely in deciphering the histone codes and their biological influence. In this review, we discuss the histone modification patterns found in genome-wide studies in different biological models and how they influence cell differentiation and carcinogenesis.
Author	Ekwall, Karl Lennartsson, Andreas
Author_xml	– sequence: 1 givenname: Andreas surname: Lennartsson fullname: Lennartsson, Andreas – sequence: 2 givenname: Karl surname: Ekwall fullname: Ekwall, Karl email: karl.ekwall@ki.se
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19168116$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:119329186$$DView record from Swedish Publication Index
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Snippet	The eukaryotic DNA is wrapped around histone octamers, which consist of four different histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is...
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SubjectTerms	Animals Cancer Cell Differentiation Chromatin Epigenesis, Genetic Epigenetic Histone code Histone modification Histones - metabolism Humans Neoplasms - etiology
Title	Histone modification patterns and epigenetic codes
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