Infection With Helicobacter pylori Is Not a Major Independent Risk Factor for Stable Coronary Heart Disease Lack of a Role of Cytotoxin-Associated Protein A–Positive Strains and Absence of a Systemic Inflammatory Response

• Published in: Circulation (New York, N.Y.) Vol. 100; no. 23; pp. 2326 - 2331
• Main Authors: Koenig, Wolfgang, Rothenbacher, Dietrich, Hoffmeister, Albrecht, Miller, Markus, Bode, Guenther, Adler, Guido, Hombach, Vinzenz, März, Winfried, Pepys, Mark B., Brenner, Hermann
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 07.12.1999; American Heart Association, Inc
• Subjects: Aged; Antibodies, Bacterial - blood; Antigens, Bacterial - analysis; Bacterial Proteins - analysis; Biological and medical sciences; Biomarkers; Breath Tests; Carbon Isotopes; Cardiology. Vascular system; Case-Control Studies; Coronary Disease - epidemiology; Coronary Disease - microbiology; Coronary heart disease; Female; Heart; Helicobacter Infections - epidemiology; Helicobacter Infections - immunology; Helicobacter pylori - chemistry; Helicobacter pylori - immunology; Helicobacter pylori - pathogenicity; Humans; Immunoglobulin A - blood; Immunoglobulin G - blood; Male; Medical sciences; Middle Aged; Risk Factors; Seroepidemiologic Studies; Systemic Inflammatory Response Syndrome - epidemiology; Systemic Inflammatory Response Syndrome - immunology; Urea - analysis; Virulence; Infection; Human; Spirillales; Helicobacter pylori; Antibody; Risk factor; Spirillaceae; Cardiovascular disease; Bacteria; Inflammation; Coronary heart disease

Background —There is controversy about the association between Helicobacter pylori infection and manifestations of coronary heart disease (CHD), the potential role of the more virulent H pylori strains, and whether or not a positive serostatus is related to increased levels of markers of systemic in...