Profile of Daily Life in Children With Brain Tumors: An Assessment of Health-Related Quality of Life
The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of thei...
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Published in | Journal of clinical oncology Vol. 23; no. 24; pp. 5493 - 5500 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Baltimore, MD
American Society of Clinical Oncology
20.08.2005
Lippincott Williams & Wilkins |
Subjects | |
Online Access | Get full text |
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Abstract | The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of their daily lives.
The PedsQL was administered to all patients seen in the neuro-oncology clinic at Lucile Packard Children's Hospital (Palo Alto, CA) from December 2001, to September 2002. Patients were compared with healthy controls by using two-sided t tests to evaluate statistically significant differences.
One hundred thirty-four patients (73 male; mean age +/- standard deviation, 11.8 +/- 5.4 years; 55 had low-grade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant astrocytoma, nine had germ-cell tumor, and 21 had other types of tumors) were assessed, each in less than 20 minutes. Scores on both child and parent-proxy reports for the total HRQOL, psychosocial, physical, emotional, social, and school-functioning scales were all significantly lower than controls (P < .01). Patients with low-grade glioma were reported to have the highest total HRQOL. Children receiving radiation therapy (XRT) but no chemotherapy had significantly lower total, psychosocial, emotional, and social functioning than those receiving other treatments, including XRT plus chemotherapy.
The PedsQL can be used to assess HRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children. Children receiving XRT fare worse overall; chemotherapy added to XRT does not seem to worsen HRQOL. Assessment of HRQOL should be included as an outcome in future clinical trials. |
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AbstractList | The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of their daily lives.
The PedsQL was administered to all patients seen in the neuro-oncology clinic at Lucile Packard Children's Hospital (Palo Alto, CA) from December 2001, to September 2002. Patients were compared with healthy controls by using two-sided t tests to evaluate statistically significant differences.
One hundred thirty-four patients (73 male; mean age +/- standard deviation, 11.8 +/- 5.4 years; 55 had low-grade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant astrocytoma, nine had germ-cell tumor, and 21 had other types of tumors) were assessed, each in less than 20 minutes. Scores on both child and parent-proxy reports for the total HRQOL, psychosocial, physical, emotional, social, and school-functioning scales were all significantly lower than controls (P < .01). Patients with low-grade glioma were reported to have the highest total HRQOL. Children receiving radiation therapy (XRT) but no chemotherapy had significantly lower total, psychosocial, emotional, and social functioning than those receiving other treatments, including XRT plus chemotherapy.
The PedsQL can be used to assess HRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children. Children receiving XRT fare worse overall; chemotherapy added to XRT does not seem to worsen HRQOL. Assessment of HRQOL should be included as an outcome in future clinical trials. PURPOSEThe survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of their daily lives.PATIENTS AND METHODSThe PedsQL was administered to all patients seen in the neuro-oncology clinic at Lucile Packard Children's Hospital (Palo Alto, CA) from December 2001, to September 2002. Patients were compared with healthy controls by using two-sided t tests to evaluate statistically significant differences.RESULTSOne hundred thirty-four patients (73 male; mean age +/- standard deviation, 11.8 +/- 5.4 years; 55 had low-grade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant astrocytoma, nine had germ-cell tumor, and 21 had other types of tumors) were assessed, each in less than 20 minutes. Scores on both child and parent-proxy reports for the total HRQOL, psychosocial, physical, emotional, social, and school-functioning scales were all significantly lower than controls (P < .01). Patients with low-grade glioma were reported to have the highest total HRQOL. Children receiving radiation therapy (XRT) but no chemotherapy had significantly lower total, psychosocial, emotional, and social functioning than those receiving other treatments, including XRT plus chemotherapy.CONCLUSIONThe PedsQL can be used to assess HRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children. Children receiving XRT fare worse overall; chemotherapy added to XRT does not seem to worsen HRQOL. Assessment of HRQOL should be included as an outcome in future clinical trials. Purpose The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We aimed to show that universal assessment of HRQOL could be obtained easily by using the PedsQL 4.0 and to provide a composite profile of their daily lives. Patients and Methods The PedsQL was administered to all patients seen in the neuro-oncology clinic at Lucile Packard Children's Hospital (Palo Alto, CA) from December 2001, to September 2002. Patients were compared with healthy controls by using two-sided t tests to evaluate statistically significant differences. Results One hundred thirty-four patients (73 male; mean age ± standard deviation, 11.8 ± 5.4 years; 55 had low-grade glioma, 32 had medulloblastoma/primitive neuroectodermal tumor/embryonal tumor, 17 had malignant astrocytoma, nine had germ-cell tumor, and 21 had other types of tumors) were assessed, each in less than 20 minutes. Scores on both child and parent-proxy reports for the total HRQOL, psychosocial, physical, emotional, social, and school-functioning scales were all significantly lower than controls (P < .01). Patients with low-grade glioma were reported to have the highest total HRQOL. Children receiving radiation therapy (XRT) but no chemotherapy had significantly lower total, psychosocial, emotional, and social functioning than those receiving other treatments, including XRT plus chemotherapy. Conclusion The PedsQL can be used to assess HRQOL rapidly and easily in children with CNS tumors, who have significantly worse HRQOL than healthy children. Children receiving XRT fare worse overall; chemotherapy added to XRT does not seem to worsen HRQOL. Assessment of HRQOL should be included as an outcome in future clinical trials. |
Author | James W. Varni Ruth K. Rosenblum Paul G. Fisher Gary V. Dahl Sarah S. Donaldson Meagan F. Lansdale Sundeep R. Bhat Iris C. Gibbs Tress L. Goodwin Stephen L. Huhn Tasha M. Burwinkle |
Author_xml | – sequence: 1 givenname: Sundeep R surname: BHAT fullname: BHAT, Sundeep R organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 2 givenname: Tress L surname: GOODWIN fullname: GOODWIN, Tress L organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 3 givenname: Paul G surname: FISHER fullname: FISHER, Paul G organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 4 givenname: Tasha M surname: BURWINKLE fullname: BURWINKLE, Tasha M organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 5 givenname: Meagan F surname: LANSDALE fullname: LANSDALE, Meagan F organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 6 givenname: Gary V surname: DAHL fullname: DAHL, Gary V organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 7 givenname: Stephen L surname: HUHN fullname: HUHN, Stephen L organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 8 givenname: Iris C surname: GIBBS fullname: GIBBS, Iris C organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 9 givenname: Sarah S surname: DONALDSON fullname: DONALDSON, Sarah S organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 10 givenname: Ruth K surname: ROSENBLUM fullname: ROSENBLUM, Ruth K organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States – sequence: 11 givenname: James W surname: VARNI fullname: VARNI, James W organization: Department of Anesthesiology, University of Washington Medical Center, Seattle, WA, United States |
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Cites_doi | 10.3322/canjclin.53.1.5 10.1200/JCO.2003.01.202 10.1200/JCO.1991.9.4.592 10.1002/cncr.10428 10.1023/A:1006145724500 10.3171/jns.1994.80.6.1004 10.1002/mpo.2950180410 10.1001/jama.290.12.1583 10.1159/000120795 10.1097/00005650-200108000-00006 10.1002/1531-8249(199912)46:6<834::AID-ANA5>3.0.CO;2-M 10.1056/NEJMoa022672 10.1002/(SICI)1096-911X(199812)31:6<506::AID-MPO7>3.0.CO;2-X 10.1016/S0959-8049(98)00366-9 10.1037/0033-2909.101.2.213 10.1002/ana.410320411 |
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Snippet | The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this population. We... Purpose The survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this... PURPOSEThe survival of children with CNS tumors approaches 70%, yet health-related quality of life (HRQOL) has not been investigated rigorously in this... |
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SubjectTerms | Adolescent Analysis of Variance Biological and medical sciences Brain Neoplasms - physiopathology Brain Neoplasms - psychology Brain Neoplasms - therapy Case-Control Studies Child Child, Preschool Female Humans Male Medical sciences Neurology Quality of Life Sickness Impact Profile Surveys and Questionnaires Tumors Tumors of the nervous system. Phacomatoses |
Title | Profile of Daily Life in Children With Brain Tumors: An Assessment of Health-Related Quality of Life |
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