Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1197; p. 123231
• Main Authors: Liu, Lu, Yang, Le, Li, Wei, Chen, Xiaoyan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2022
• Subjects: acetonitrile; Active metabolite (HAS-719); Almonertinib; ammonium acetate; chemical species; electrospray ionization mass spectrometry; enzymes; Food and Drug Administration; formic acid; humans; itraconazole; LC–MS/MS; metabolites; Pharmacokinetic drug-drug interaction; pharmacokinetics; rifampicin; Pharmacokinetic drug-drug interaction; Active metabolite (HAS-719); LC–MS/MS; Almonertinib

•A LC-MS/MS method for the quantification of almonertinib/HAS-719 in DDI studies.•Acceptable wide linear range and mutual interference of analytes.•The pharmacokinetics evaluation of almonertinib in healthy subjects.•Significant effects of itraconazole and rifampicin on the pharmacokinetics of almon...