A Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes

• Published in: Toxicological sciences Vol. 136; no. 2; pp. 595 - 604
• Main Authors: Rowlands, J. Craig, Budinsky, Robert, Gollapudi, Bhaskar, Black, Michael B., Wolfinger, Russell D., Cukovic, Daniela, Dombkowski, Alan, Thompson, Chad M., Urban, Jonathan D., Thomas, Russell S.
• Format: Journal Article
• Language: English
• Published: United States 01.12.2013
• Subjects: Animals; Cells, Cultured; Dioxins - toxicity; Female; Gene Expression Regulation - drug effects; Genomics; Hepatocytes - drug effects; Hepatocytes - metabolism; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Signal Transduction; risk assessment; dioxin; dose response; toxicogenomics; aryl hydrocarbon receptor

Toxic equivalency factors (TEFs) for dioxin-like compounds are largely based on relative potency (REP) values derived from biochemical endpoints such as enzyme activity. As of yet, REPs based on gene expression changes have not been accounted for in the TEF values. In this study, primary rat hepatoc...