Dysregulation of MAP Kinase Signaling Pathways Including p38MAPK, SAPK/JNK, and ERK1/2 in Cultured Rat Cerebellar Astrocytes Exposed to Diphenylarsinic Acid

• Published in: Toxicological sciences Vol. 156; no. 2; p. 509
• Main Authors: Negishi, Takayuki, Matsumoto, Mami, Kobayashi, Yayoi, Kojima, Mikiya, Sakaguchi, Fumika, Takahata, Kazuaki, Kanehira, Tomoko, Arakaki, Rina, Aoyama, Yohei, Yoshida, Hikari, Yamada, Rena, Sumiyoshi, Nobutaka, Tashiro, Tomoko, Hirano, Seishiro, Yoshida, Kenji, Yukawa, Kazunori
• Format: Journal Article
• Language: English
• Published: United States 01.04.2017
• Subjects: Animals; Arsenicals - pharmacology; Astrocytes - drug effects; Astrocytes - enzymology; Blotting, Western; Cells, Cultured; Cerebellum - cytology; Cerebellum - drug effects; Cerebellum - enzymology; Immunoenzyme Techniques; MAP Kinase Signaling System - drug effects; Rats; cytokine; diphenylarsinic acid; MAP kinase; astrocyte; oxidative stress

Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported that DPAA i...