Assisting dementia diagnosis through the electrochemical immunosensing of glial fibrillary acidic protein

• Published in: Talanta (Oxford) Vol. 246; p. 123526
• Main Authors: Ozcelikay, Goksu, Gamella, María, Unal, Mehmet Altay, Gucuyener, Kıvılcım, Montero-Calle, Ana, Barderas, Rodrigo, Pingarrón, José M., Campuzano, Susana, Ozkan, Sibel A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2022
• Subjects: Alzheimer disease; antibodies; blood serum; brain; Brain tissue extracts; carbon; carboxylic acids; cerebrospinal fluid; detection limit; electrochemistry; enzyme-linked immunosorbent assay; GFAP; hydrogen peroxide; hydroquinone; Immunoplatform; magnetism; MBs; microbeads; prognosis; Immunoplatform; Brain tissue extracts; Alzheimer disease; GFAP; MBs

Glial fibrillary acidic protein (GFAP) is a member of the intermediate filament family of proteins with increased levels in serum and cerebrospinal fluid of patients with Alzheimer disease (AD) and other neurodegenerative diseases (NDs), such as vascular dementia (VD). This work describes the first...