Multifunctional pH-responsive hydrogel dressings based on carboxymethyl chitosan: Synthesis, characterization fostering the wound healing

• Published in: Carbohydrate polymers Vol. 341; p. 122348
• Main Authors: Xiong, Mingxin, Chen, Yu, Hu, Han-Jian, Cheng, Hao, Li, Wei-Xiong, Tang, Shipeng, Hu, Xiaolong, Lan, Ling-Min, Zhang, Hongyan, Jiang, Gang-Biao
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024
• Subjects: adhesion; Animals; Anti-bacterial; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibiotics; antioxidant activity; bacterial infections; Bandages; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Carboxymethyl chitosan; chitosan; Chitosan - analogs & derivatives; Chitosan - chemical synthesis; Chitosan - chemistry; Chitosan - pharmacology; coagulants; collagen; cross-linking reagents; drug resistance; granulation tissue; health services; Hydrogel dressing; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogels - pharmacology; Hydrogen-Ion Concentration; macrophages; Male; Mice; pH-responsive; plant extracts; polyvinylpyrrolidone; Povidone - chemistry; Self-adaptive; Skin - drug effects; Skin - pathology; Staphylococcus aureus - drug effects; Tannic acid; Wound Healing - drug effects; Tannic acid; Self-adaptive; Anti-bacterial; Hydrogel dressing; Carboxymethyl chitosan; pH-responsive

Antibiotic abuse is increasing the present rate of drug-resistant bacterial wound infections, producing a significant healthcare burden globally. Herein, we prepared a pH-responsive CMCS/PVP/TA (CPT) multifunctional hydrogel dressing by embedding the natural plant extract TA as a nonantibiotic and c...