MiR-137 Targets the 3′ Untranslated Region of MSH2: Potential Implications in Lynch Syndrome-Related Colorectal Cancer

• Published in: Cancers Vol. 13; no. 18; p. 4662
• Main Authors: Liccardo, Raffaella, Sessa, Raffaele, Trombetti, Silvia, De Rosa, Marina, Izzo, Paola, Grosso, Michela, Duraturo, Francesca
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 17.09.2021; MDPI
• Subjects: 3' Untranslated regions; Antibiotics; Apoptosis; Bioinformatics; Cell cycle; Cell division; Cell growth; Cell proliferation; Colorectal cancer; Colorectal carcinoma; DNA damage; Experiments; Gene expression; Genomes; Genomic instability; MicroRNAs; miRNA; Mismatch repair; Molecular modelling; MSH2 protein; Mutagenesis; Mutation; Proteins; Site-directed mutagenesis; Software; Tumorigenesis; United States > US; Massachusetts; Germany

Mismatch Repair (MMR) gene dysregulation plays a fundamental role in Lynch Syndrome (LS) pathogenesis, a form of hereditary colorectal cancer. Loss or overexpression of key MMR genes leads to genome instability and tumorigenesis; however, the mechanisms controlling MMR gene expression are unknown. O...