Negative regulation of human mononuclear phagocyte function

• Published in: Mucosal immunology Vol. 6; no. 2; pp. 205 - 223
• Main Authors: Hedl, M, Abraham, C
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.03.2013; Nature Publishing Group US; Elsevier Limited
• Subjects: 631/250/2502; 631/250/2504/342/1726; 631/250/262/2106; 631/250/516; Allergology; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; Cell Differentiation; Cell Movement; Gastroenterology; Homeostasis - immunology; Humans; Immunology; Intestinal Mucosa - metabolism; Intestines - immunology; Macrophages - immunology; Macrophages - metabolism; Mice; Monocytes - cytology; Monocytes - immunology; Organ Specificity - immunology; Phagocytes - immunology; Phagocytes - metabolism; Receptors, Pattern Recognition - metabolism; review; Signal Transduction
• ISSN: 1933-0219; 1935-3456; 1935-3456
• DOI: 10.1038/mi.2012.139

At mucosal surfaces, phagocytes such as macrophages coexist with microbial communities; highly controlled regulation of these interactions is essential for immune homeostasis. Pattern-recognition receptors (PRRs) are critical in recognizing and responding to microbial products, and they are subject...