Abnormal erythrocyte band 4.1 protein in myelodysplastic syndrome with elliptocytosis

• Published in: British journal of haematology Vol. 85; no. 2; p. 387
• Main Authors: Ideguchi, H, Yamada, Y, Kondo, S, Tamura, K, Makino, S, Hamasaki, N
• Format: Journal Article
• Language: English
• Published: England 01.10.1993
• Subjects: Anemia, Refractory - blood; Anemia, Refractory - pathology; Base Sequence; Bone Marrow - pathology; Cytoskeletal Proteins; DNA - chemistry; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane - chemistry; Erythrocytes, Abnormal - physiology; Glycophorin - analysis; Humans; Immunoblotting; Male; Membrane Proteins - blood; Middle Aged; Molecular Sequence Data; Neuropeptides; Polymerase Chain Reaction; Spectrin - analysis

A case of myelodysplastic syndrome with haemolytic anaemia and a marked elliptocytosis is reported. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of erythrocyte membrane proteins revealed that the patient's band 4.1 was decreased to about 50-70% of that of control and co...