In vitro characterization of a slow release system of polylactic acid and rhBMP2

• Published in: Journal of biomedical materials research. Part A Vol. 83A; no. 2; pp. 455 - 462
• Main Authors: Schliephake, H., Weich, H. A., Schulz, J., Gruber, R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2007
• Subjects: Absorbable Implants; Alkaline Phosphatase - biosynthesis; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins - metabolism; bone morphogenic proteins; Cell Line; controlled release; Delayed-Action Preparations - metabolism; Enzyme Induction; Gases; growth factors; Humans; Hydrogen-Ion Concentration; Intercellular Signaling Peptides and Proteins - metabolism; Lactic Acid - metabolism; Mice; Microscopy, Electron, Scanning; Polyesters; polymers; Polymers - metabolism; Recombinant Proteins - metabolism; Transforming Growth Factor beta - metabolism

The aim of the present report was to test a system for controlled release of recombinant human bone morphogenic protein (rhBMP2) incorporated into polylactic acid (PLA) implants. Incorporation of rhBMP2 into the polymer was accomplished by mixing rhBMP2 solution with granular powder of amorphous pol...