Human parvovirus B19 in clotting factor concentrates: B19 DNA detection by the nested polymerase chain reaction

• Published in: British journal of haematology Vol. 81; no. 3; p. 407
• Main Authors: Zakrzewska, K, Azzi, A, Patou, G, Morfini, M, Rafanelli, D, Pattison, J R
• Format: Journal Article
• Language: English
• Published: England 01.07.1992
• Subjects: Base Sequence; Blood Coagulation Factors - genetics; Blotting, Southern; DNA, Viral - analysis; DNA, Viral - genetics; Erythema Infectiosum - genetics; Humans; Molecular Sequence Data; Parvovirus B19, Human - genetics; Parvovirus B19, Human - isolation & purification; Polymerase Chain Reaction

The presence of B19 parvovirus in plasma from blood donors is seldom demonstrable, but clotting factor concentrates, prepared from large plasma pools, may be able to transmit B19 virus infection, and the effectiveness of different chemical and physical treatment to inactivate this virus is not yet k...