Continuous and long‐term treatment is more important than dosage for the protective effect of thiazide use on bone metabolism and fracture risk

• Published in: Journal of internal medicine Vol. 279; no. 1; pp. 110 - 122
• Main Authors: Kruse, C., Eiken, P., Vestergaard, P.
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Aged; Bone and Bones - drug effects; Bone and Bones - metabolism; bone metabolism; Cohort Studies; Comorbidity; Databases as Topic; diuretics; Female; fractures; Fractures, Bone - prevention & control; Humans; Male; osteoporosis; Retrospective Studies; Sodium Chloride Symporter Inhibitors - administration & dosage; Sodium Chloride Symporter Inhibitors - therapeutic use; thiazides; bone metabolism; osteoporosis; diuretics; fractures; thiazides

Background Data from observational studies have suggested that thiazide diuretics protect against fractures. Few studies have investigated time frames from initiation of treatment to fracture occurrence. Objective To evaluate the time to spinal, hip, femur, wrist and upper extremity fracture occurre...