Therapeutic potential of purinergic signalling for diseases of the urinary tract

• Published in: BJU international Vol. 107; no. 2; pp. 192 - 204
• Main Author: Burnstock, Geoffrey
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2011; Wiley-Blackwell
• Subjects: Adenosine Triphosphate - physiology; ATP; Biological and medical sciences; co‐transmitter; Female; Humans; Male; Medical sciences; NANC; Nephrology. Urinary tract diseases; Nitric Oxide - metabolism; purinergic; Purinergic P2X Receptor Antagonists - therapeutic use; review; Signal Transduction - physiology; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urination - physiology; Urologic Diseases - physiopathology; Urologic Diseases - therapy; Human; Nephrology; Lower urinary tract; Urinary system disease; Review; Urinary tract disease; NANC; Urology; co-transmitter; Signal transduction; Treatment; purinergic; Purinergic receptor; ATP

What’s known on the subject? and What does the study add? Purinergic signalling, i.e. ATP acting as an extracellular messenger, has been implicated in control of urinary tract function since 1972. For example, it was shown to be a cotransmitter with acetylcholine in parasympathetic control of bladde...