Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma

• Published in: Dermatologic surgery Vol. 23; no. 8; pp. 695 - 700
• Main Authors: VERHAEGH, MARC E.J.M., ARENDS, JAN‐WILLEM, MAJOIE, I.M. LEONIE, HOEKZEMA, RICK, NEUMANN, H.A. MARTINO
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.1997; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, CD34 - analysis; Antigens, CD34 - genetics; Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Carcinoma, Basal Cell - pathology; Cell Differentiation; Cell Division; Coloring Agents; Cytoplasm - ultrastructure; Dermatology; Diagnosis, Differential; Disease-Free Survival; Endothelium, Vascular - pathology; Evaluation Studies as Topic; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Keratinocytes - pathology; Male; Medical sciences; Middle Aged; Neoplasms, Basal Cell - pathology; Proto-Oncogene Proteins c-bcl-2 - analysis; Proto-Oncogene Proteins c-bcl-2 - genetics; Reproducibility of Results; Skin Neoplasms - pathology; Transforming Growth Factor beta - analysis; Transforming Growth Factor beta - genetics; Tumors of the skin and soft tissue. Premalignant lesions; Human; Immunohistochemistry; Skin disease; Basal cell carcinoma; Transforming growth factor β; Trichoepithelioma; Cytokine; Hair follicle; Malignant tumor; Cell surface; Differential diagnostic; Antigen; Pathology; Benign neoplasm; Protooncogene

background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. objective Recently, bcl‐2 and CD34 have been reported as reliable markers in distingui...