Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma
background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. objective Recently, bcl‐2 and CD34 have been reported as reliable markers in distingui...
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Published in | Dermatologic surgery Vol. 23; no. 8; pp. 695 - 700 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.1997
Blackwell |
Subjects | |
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Abstract | background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities.
objective Recently, bcl‐2 and CD34 have been reported as reliable markers in distinguishing the two types of tuntor. Transforming growth factor‐beta (TGF‐β), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study.
methods The immunohistochemical expression of TGF‐β was compared with the distribution patterns of bcl‐2 and CD34 in five BCCs, five TEs, and seven borderline cases.
results All five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF‐β. whereas four of five BCCs were TGF‐β negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF‐β positivity in combination with negative bcl‐2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC.
conclusion The TGF‐β staining pattern appears to be a helpful additional marker together with bcl‐2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management. |
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AbstractList | BACKGROUNDTrichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. OBJECTIVERecently, bcl-2 and CD34 have been reported as reliable markers in distinguishing the two types of tumor. Transforming growth factor-beta (TGF-beta), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study. METHODSThe immunohistochemical expression of TGF-beta was compared with the distribution patterns of bcl-2 and CD34 in five BCCs, five TEs, and seven borderline cases. RESULTSAll five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF-beta, whereas four of five BCCs were TGF-beta negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF-beta positivity in combination with negative bcl-2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC. CONCLUSIONThe TGF-beta staining pattern appears to be a helpful additional marker together with bcl-2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management. Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. Recently, bcl-2 and CD34 have been reported as reliable markers in distinguishing the two types of tumor. Transforming growth factor-beta (TGF-beta), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study. The immunohistochemical expression of TGF-beta was compared with the distribution patterns of bcl-2 and CD34 in five BCCs, five TEs, and seven borderline cases. All five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF-beta, whereas four of five BCCs were TGF-beta negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF-beta positivity in combination with negative bcl-2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC. The TGF-beta staining pattern appears to be a helpful additional marker together with bcl-2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management. background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities. objective Recently, bcl‐2 and CD34 have been reported as reliable markers in distinguishing the two types of tuntor. Transforming growth factor‐beta (TGF‐β), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study. methods The immunohistochemical expression of TGF‐β was compared with the distribution patterns of bcl‐2 and CD34 in five BCCs, five TEs, and seven borderline cases. results All five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF‐β. whereas four of five BCCs were TGF‐β negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF‐β positivity in combination with negative bcl‐2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC. conclusion The TGF‐β staining pattern appears to be a helpful additional marker together with bcl‐2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management. |
Author | NEUMANN, H.A. MARTINO ARENDS, JAN‐WILLEM MAJOIE, I.M. LEONIE HOEKZEMA, RICK VERHAEGH, MARC E.J.M. |
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Cites_doi | 10.1073/pnas.90.13.6076 10.1001/archderm.1994.01690050057008 10.1111/j.1600-0560.1996.tb01288.x 10.1111/j.1365-2133.1994.tb08453.x 10.1111/j.1365-2133.1993.tb03312.x 10.1016/S0190-9622(89)70220-6 10.1182/blood.V67.3.842.842 10.1016/0092-8674(93)80066-N 10.1001/archderm.1991.04510010091009 10.1016/0012-1606(88)90337-5 10.1038/348334a0 10.1111/j.1365-2133.1995.tb00719.x |
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Keywords | Human Immunohistochemistry Skin disease Basal cell carcinoma Transforming growth factor β Trichoepithelioma Cytokine Hair follicle Malignant tumor Cell surface Differential diagnostic Antigen Pathology Benign neoplasm Protooncogene |
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References | 1990; 3 1993; 129 1990; 348 1989; 21 1994; 130 1986; 67 1994; 131 1993; 75 1993 1993; 90 1992 1988; 130 1995; 132 1991; 127 1996; 23 Andrews (10.1111/j.1524-4725.1997.tb00392.x-BIB10|cit10) 1986; 67 Glick (10.1111/j.1524-4725.1997.tb00392.x-BIB14|cit14) 1993; 90 Walsh (10.1111/j.1524-4725.1997.tb00392.x-BIB2|cit2) 1990; 3 Stamp (10.1111/j.1524-4725.1997.tb00392.x-BIB13|cit13) 1993; 129 Kirchmann (10.1111/j.1524-4725.1997.tb00392.x-BIB3|cit3) 1994; 130 Ackerman (10.1111/j.1524-4725.1997.tb00392.x-BIB1|cit1) 1993 Hockenbery (10.1111/j.1524-4725.1997.tb00392.x-BIB8|cit8) 1993; 75 Nickoloff (10.1111/j.1524-4725.1997.tb00392.x-BIB11|cit11) 1991; 127 Verhaegh (10.1111/j.1524-4725.1997.tb00392.x-BIB9|cit9) 1995; 132 Hockenbery (10.1111/j.1524-4725.1997.tb00392.x-BIB7|cit7) 1990; 348 Smoller (10.1111/j.1524-4725.1997.tb00392.x-BIB4|cit4) 1994; 131 Eusebio (10.1111/j.1524-4725.1997.tb00392.x-BIB15|cit15) 1996; 23 Ackerman (10.1111/j.1524-4725.1997.tb00392.x-BIB6|cit6) 1992 Brooke (10.1111/j.1524-4725.1997.tb00392.x-BIB5|cit5) 1989; 21 Rizzino (10.1111/j.1524-4725.1997.tb00392.x-BIB12|cit12) 1988; 130 |
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Snippet | background Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many... Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and... BACKGROUNDTrichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many... |
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SubjectTerms | Adult Aged Aged, 80 and over Antigens, CD34 - analysis Antigens, CD34 - genetics Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Carcinoma, Basal Cell - pathology Cell Differentiation Cell Division Coloring Agents Cytoplasm - ultrastructure Dermatology Diagnosis, Differential Disease-Free Survival Endothelium, Vascular - pathology Evaluation Studies as Topic Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Keratinocytes - pathology Male Medical sciences Middle Aged Neoplasms, Basal Cell - pathology Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics Reproducibility of Results Skin Neoplasms - pathology Transforming Growth Factor beta - analysis Transforming Growth Factor beta - genetics Tumors of the skin and soft tissue. Premalignant lesions |
Title | Transforming Growth Factor‐Beta and bcl‐2 Distribution Patterns Distinguish Trichoepithelioma from Basal Cell Carcinoma |
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