Binding Epitopes of Gangliosides to their Neuronal Receptor, Myelin-Associated Glycoprotein, from Saturation Transfer Difference NMR

• Published in: Chembiochem : a European journal of chemical biology Vol. 9; no. 18; pp. 2946 - 2949
• Main Authors: Shin, So-Young, Gäthje, Heiko, Schwardt, Oliver, Gao, Gan-Pan, Ernst, Beat, Kelm, Soerge, Meyer, Bernd
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 15.12.2008; WILEY‐VCH Verlag
• Subjects: axonal regeneration; Binding Sites; Carbohydrate Conformation; carbohydrates; epitopes; Epitopes - metabolism; Gangliosides - chemistry; Gangliosides - pharmacology; Myelin-Associated Glycoprotein - antagonists & inhibitors; Myelin-Associated Glycoprotein - chemistry; Myelin-Associated Glycoprotein - metabolism; myelin‐associated glycoprotein; Nuclear Magnetic Resonance, Biomolecular; saturation transfer difference NMR

MAGnificent analysis to remove ambiguity: The binding epitopes of tri‐ and tetrasaccharide ligands in their interactions with the myelin‐associated glycoprotein (MAG) have been studied by using saturation transfer difference NMR, in which the signal intensities can help to resolve overlapped HSQC si...