Binding Epitopes of Gangliosides to their Neuronal Receptor, Myelin-Associated Glycoprotein, from Saturation Transfer Difference NMR
MAGnificent analysis to remove ambiguity: The binding epitopes of tri‐ and tetrasaccharide ligands in their interactions with the myelin‐associated glycoprotein (MAG) have been studied by using saturation transfer difference NMR, in which the signal intensities can help to resolve overlapped HSQC si...
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| Published in | Chembiochem : a European journal of chemical biology Vol. 9; no. 18; pp. 2946 - 2949 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
Wiley-VCH Verlag
15.12.2008
WILEY‐VCH Verlag |
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| Abstract | MAGnificent analysis to remove ambiguity: The binding epitopes of tri‐ and tetrasaccharide ligands in their interactions with the myelin‐associated glycoprotein (MAG) have been studied by using saturation transfer difference NMR, in which the signal intensities can help to resolve overlapped HSQC signals. In the figure, the signals of the protons with the closest proximity to the protein are shown in red (30–60 %) or blue (61–100 %). |
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| AbstractList | MAGnificent analysis to remove ambiguity: The binding epitopes of tri‐ and tetrasaccharide ligands in their interactions with the myelin‐associated glycoprotein (MAG) have been studied by using saturation transfer difference NMR, in which the signal intensities can help to resolve overlapped HSQC signals. In the figure, the signals of the protons with the closest proximity to the protein are shown in red (30–60 %) or blue (61–100 %). |
| Author | Gäthje, Heiko Schwardt, Oliver Meyer, Bernd Kelm, Soerge Gao, Gan-Pan Ernst, Beat Shin, So-Young |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19040245$$D View this record in MEDLINE/PubMed |
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| Snippet | MAGnificent analysis to remove ambiguity: The binding epitopes of tri‐ and tetrasaccharide ligands in their interactions with the myelin‐associated... MAGnificent analysis to remove ambiguity: The binding epitopes of tri- and tetrasaccharide ligands in their interactions with the myelin-associated... |
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| SubjectTerms | axonal regeneration Binding Sites Carbohydrate Conformation carbohydrates epitopes Epitopes - metabolism Gangliosides - chemistry Gangliosides - pharmacology Myelin-Associated Glycoprotein - antagonists & inhibitors Myelin-Associated Glycoprotein - chemistry Myelin-Associated Glycoprotein - metabolism myelin‐associated glycoprotein Nuclear Magnetic Resonance, Biomolecular saturation transfer difference NMR |
| Title | Binding Epitopes of Gangliosides to their Neuronal Receptor, Myelin-Associated Glycoprotein, from Saturation Transfer Difference NMR |
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