Bilateral inguinal hernia with dislocation of great saphenous vein as complication of long‐standing granulomatous slack skin: a case report
Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes infiltrate with alteration of the dermal elastic tissue and consequent elastolysis, elastophagocytosis and numerous giant cells. Clinically, a developme...
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Published in | Journal of the European Academy of Dermatology and Venereology Vol. 20; no. 5; pp. 595 - 598 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.2006
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Abstract | Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes infiltrate with alteration of the dermal elastic tissue and consequent elastolysis, elastophagocytosis and numerous giant cells. Clinically, a development of unelastic, slack skin, especially on flexural areas, is observed. Hereby, we describe a man with a 12‐year history of GSS. In 2002, for practical (limitation of movement, deambulation) and cosmetic reasons, he underwent the surgical excision of loose and sagging skinfold over inguinal area, and, afterwards, of the opposite affected inguinal skin. The surgical treatment of bilateral inguinal hernia with reposition of inguinal dislocated vasculature is also reported. In both cases the excised material confirmed the former diagnosis of GSS and revealed a very deep, muscular infiltrate of neoplastic lymphocytes. One year later, a new excision of GSS on the axillae was made. Now, after 2 years, deambulation keeps improving, although an initial relapse of the inguinal slack skin has been observed. |
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AbstractList | Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes infiltrate with alteration of the dermal elastic tissue and consequent elastolysis, elastophagocytosis and numerous giant cells. Clinically, a development of unelastic, slack skin, especially on flexural areas, is observed. Hereby, we describe a man with a 12-year history of GSS. In 2002, for practical (limitation of movement, deambulation) and cosmetic reasons, he underwent the surgical excision of loose and sagging skinfold over inguinal area, and, afterwards, of the opposite affected inguinal skin. The surgical treatment of bilateral inguinal hernia with reposition of inguinal dislocated vasculature is also reported. In both cases the excised material confirmed the former diagnosis of GSS and revealed a very deep, muscular infiltrate of neoplastic lymphocytes. One year later, a new excision of GSS on the axillae was made. Now, after 2 years, deambulation keeps improving, although an initial relapse of the inguinal slack skin has been observed. Abstract Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes infiltrate with alteration of the dermal elastic tissue and consequent elastolysis, elastophagocytosis and numerous giant cells. Clinically, a development of unelastic, slack skin, especially on flexural areas, is observed. Hereby, we describe a man with a 12‐year history of GSS. In 2002, for practical (limitation of movement, deambulation) and cosmetic reasons, he underwent the surgical excision of loose and sagging skinfold over inguinal area, and, afterwards, of the opposite affected inguinal skin. The surgical treatment of bilateral inguinal hernia with reposition of inguinal dislocated vasculature is also reported. In both cases the excised material confirmed the former diagnosis of GSS and revealed a very deep, muscular infiltrate of neoplastic lymphocytes. One year later, a new excision of GSS on the axillae was made. Now, after 2 years, deambulation keeps improving, although an initial relapse of the inguinal slack skin has been observed. |
Author | Borroni, RG Tinozzi, FP Borroni, G Niebel, T Brazzelli, V Benedetti, M Vassallo, C Paulli, M |
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References | 1994; 2 1987; 89 2002; 147 1996; 18 2002; 29 1973; 107 1994; 131 1998; 196 1988; 12 2002; 3 2003; 206 1978 1968; 75 Basex A (e_1_2_4_2_2) 1968; 75 Convit J (e_1_2_4_9_2) 1973; 107 e_1_2_4_4_2 e_1_2_4_5_2 e_1_2_4_8_2 e_1_2_4_7_2 e_1_2_4_10_2 e_1_2_4_11_2 e_1_2_4_12_2 e_1_2_4_13_2 e_1_2_4_14_2 Le Boit PE (e_1_2_4_6_2) 1994; 2 Ackerman AB (e_1_2_4_3_2) 1978 |
References_xml | – volume: 89 start-page: 183 year: 1987 end-page: 186 article-title: Granulomatous slack skin: clonal rearrangement of the T‐cell receptor βgene is evidence for the lymphoproliferative nature of a cutaneous elastolytic disorder publication-title: J Invest Dermatol – volume: 12 start-page: 83 year: 1988 end-page: 95 article-title: Granulomatous variant of cutaneous T‐cell lymphoma publication-title: Am J Surg Pathol – volume: 196 start-page: 382 year: 1998 end-page: 391 article-title: Granulomatous slack skin publication-title: Dermatology – volume: 29 start-page: 447 year: 2002 end-page: 452 article-title: The value of molecular analysis by PCR in the diagnosis of cutaneous lymphocytic infiltrates publication-title: J Cutan Pathol – volume: 3 start-page: 193 year: 2002 end-page: 215 article-title: Treatment of cutaneous T cell lymphoma: current status and future directions publication-title: Am J Clin Dermatol – volume: 147 start-page: 633 year: 2002 end-page: 639 article-title: The new World Health Organization classification of haematopoietic and lymphoid tumours: a dermatopathological perspective publication-title: Br J Dermatol – volume: 18 start-page: 199 year: 1996 end-page: 206 article-title: Granulomatous slack skin publication-title: Am J Dermatopathol – start-page: 483 year: 1978 end-page: 485 – volume: 131 start-page: 275 year: 1994 end-page: 279 article-title: Granulomatous slack skin: report of a case associated with Hodgkin's disease and a review of the literature publication-title: Br J Dermatol – volume: 75 start-page: 448 year: 1968 end-page: 450 article-title: Maladie de Besnier‐Boeck‐Schaumann chalazodermique? publication-title: Bull Soc Fr Dermatol Syphiligr – volume: 2 start-page: 375 year: 1994 end-page: 389 article-title: Granulomatous slack skin publication-title: Dermatol Clin – volume: 206 start-page: 393 year: 2003 end-page: 397 article-title: Granulomatous slack skin: treatment with extensive surgery and review of the literature publication-title: Dermatology – volume: 107 start-page: 271 year: 1973 end-page: 274 article-title: Progressive, atrophying chronic granulomatous dermohypodermitis. Autoimmune disease? publication-title: Arch Dermatol – ident: e_1_2_4_8_2 doi: 10.1159/000069967 – volume: 75 start-page: 448 year: 1968 ident: e_1_2_4_2_2 article-title: Maladie de Besnier‐Boeck‐Schaumann chalazodermique? publication-title: Bull Soc Fr Dermatol Syphiligr contributor: fullname: Basex A – ident: e_1_2_4_13_2 doi: 10.1159/000017929 – start-page: 483 volume-title: Histologic Diagnosis of Inflammatory Disease year: 1978 ident: e_1_2_4_3_2 contributor: fullname: Ackerman AB – ident: e_1_2_4_5_2 doi: 10.1046/j.1365-2133.2002.05050.x – ident: e_1_2_4_12_2 doi: 10.1111/1523-1747.ep12470557 – volume: 2 start-page: 375 year: 1994 ident: e_1_2_4_6_2 article-title: Granulomatous slack skin publication-title: Dermatol Clin doi: 10.1016/S0733-8635(18)30186-4 contributor: fullname: Le Boit PE – ident: e_1_2_4_11_2 doi: 10.1034/j.1600-0560.2002.290801.x – ident: e_1_2_4_7_2 doi: 10.2165/00128071-200203030-00006 – ident: e_1_2_4_4_2 doi: 10.1097/00000478-198802000-00002 – ident: e_1_2_4_14_2 doi: 10.1111/j.1365-2133.1994.tb08505.x – ident: e_1_2_4_10_2 doi: 10.1097/00000372-199604000-00015 – volume: 107 start-page: 271 year: 1973 ident: e_1_2_4_9_2 article-title: Progressive, atrophying chronic granulomatous dermohypodermitis. Autoimmune disease? publication-title: Arch Dermatol doi: 10.1001/archderm.1973.01620170079022 contributor: fullname: Convit J |
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Snippet | Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes infiltrate... Abstract Granulomatous slack skin (GSS) represents a rare variant of mycosis fungoides, histologically characterized by a variably deep T helper lymphocytes... |
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SubjectTerms | Dermatologic Surgical Procedures elastolysis Granuloma - complications Granuloma - pathology Granuloma - surgery hernia Hernia, Inguinal - etiology Hernia, Inguinal - pathology Hernia, Inguinal - surgery Humans interferon alpha2a life style Male Middle Aged mycosis fungoides Mycosis Fungoides - complications Mycosis Fungoides - pathology Mycosis Fungoides - surgery Recurrence Saphenous Vein - pathology Skin - pathology Skin Neoplasms - complications Skin Neoplasms - pathology Skin Neoplasms - surgery slack skin |
Title | Bilateral inguinal hernia with dislocation of great saphenous vein as complication of long‐standing granulomatous slack skin: a case report |
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