Urinary matrix metalloproteinase‐7 level is associated with the presence of metastasis in bladder cancer

• Published in: BJU international Vol. 107; no. 7; pp. 1069 - 1073
• Main Authors: Szarvas, Tibor, Singer, Bernhard B., Becker, Markus, vom Dorp, Frank, Jäger, Tobias, Szendrői, Attila, Riesz, Péter, Romics, Imre, Rübben, Herbert, Ergün, Süleyman
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2011; Wiley-Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - blood; Biomarkers, Tumor - urine; bladder cancer; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; matrilysin; Matrix Metalloproteinase 7 - blood; Matrix Metalloproteinase 7 - urine; Medical sciences; metastasis; Middle Aged; MMP‐7; Nephrology. Urinary tract diseases; Prognosis; Sensitivity and Specificity; Tumors of the urinary system; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; urine; Urine; Bladder metastasis; Nephrology; Urinary system disease; Prognosis; Enzyme; Metalloendopeptidases; Urinary tract disease; Malignant tumor; Bladder cancer; Urology; Peptidases; metastasis; Hydrolases; Bladder disease; MMP-7; Cancer; Matrilysin

Study Type – Therapy (case series)
Level of Evidence 4 What’s known on the subject? and What does the study add? Recent data suggest that MMP‐7 is critically involved in metastasis formation. In accordance, we formerly found significantly elevated MMP‐7 tissue expression and serum concentration in s...