The association of exposure to DREAMS on sexually acquiring or transmitting HIV amongst adolescent girls and young women living in rural South Africa

• Published in: AIDS (London) Vol. 36; no. Supplement 1; pp. S39 - S49
• Main Authors: Mthiyane, Nondumiso, Baisley, Kathy, Chimbindi, Natsayi, Zuma, Thembelihle, Okesola, Nonhlanhla, Dreyer, Jaco, Herbst, Carina, Smit, Theresa, Danaviah, Siva, McGrath, Nuala, Harling, Guy, Sherr, Lorraine, Seeley, Janet, Floyd, Sian, Birdthistle, Isolde, Shahmanesh, Maryam
• Format: Journal Article
• Language: English
• Published: England Lippincott Williams & Wilkins 15.06.2022
• Subjects: Adolescent; Female; Herpesvirus 2, Human; HIV Infections - epidemiology; HIV Infections - prevention & control; Humans; Prospective Studies; Risk Factors; Sexual Behavior; South Africa - epidemiology; South Africa
• DOI: 10.1097/QAD.0000000000003156
• ISSN: 0269-9370

We investigate how risk of sexually acquiring or transmitting HIV in adolescent girls and young women (AGYW) changed following the real-world implementation of DREAMS (Determined, Resilient, Empowered, AIDS free, Mentored and Safe) HIV prevention programme. A representative population-based prospective cohort study of AGYW living in rural KwaZulu-Natal. Between 2017 and 2019, we interviewed a random sample of AGYW aged 13-22 years annually. We measured exposure to DREAMS as self-reported receipt of an invitation to participate and/or participation in DREAMS activities that were provided by DREAMS implementing organizations. HIV and herpes simplex virus type 2 (HSV-2) statuses were ascertained through blood tests on Dried Blood Spot (DBS). We used multivariable regression analysis to assess the association between exposure to DREAMS and risk of acquiring HIV: measured as incident HSV-2 (a proxy of sexual risk) and incident HIV;and the risk of sexually transmitting HIV: measured as being HIV positive with a detectable HIV viral load (≥50 copie/ml) on the last available DBS. We adjusted for sociodemographic, sexual relationship, and migration. Two thousand one hundred and eighty-four (86.4%) of those eligible agreed to participate and 2016 (92.3%) provided data for at least one follow-up time-point. One thousand and thirty (54%) were exposed to DREAMS;HIV and HSV-2 incidence were 2.2/100 person-years [95% confidence interval (CI) 1.66-2.86] and 17.3/100 person-years (95% CI 15.5-19.4), respectively. There was no evidence that HSV-2 and HIV incidence were lower in those exposed to DREAMS: adjusted rate ratio (aRR) 0.96 (95% CI 0.76-1.23 and 0.83 (95% CI 0.46-1.52), respectively. HIV viral load was detectable for 169 (8.9%) respondents;there was no evidence this was lower in those exposed to DREAMS with an adjusted risk difference, compared with those not exposed to DREAMS, of 0.99% (95% CI-1.52 to 3.82]. Participants who lived in peri-urban/ urban setting were more likely to have incident HIV and transmissible HIV. Both HSV-2 incidence and the transmissible HIV were associated with older age and ever having sex. Findings did not differ substantively by respondent age group. DREAMS exposure was not associated with measurable reductions in risk of sexually acquiring or transmitting HIV amongst a representative cohort of AGYW in rural South Africa.