Stent material surface and glucose activate mononuclear cells of control, type 1 and type 2 diabetes subjects

• Published in: Journal of biomedical materials research. Part A Vol. 83A; no. 1; pp. 52 - 57
• Main Authors: Harrison, Moira, Siddiq, Amer, Guildford, Anna, Bone, Adrian, Santin, Matteo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2007
• Subjects: Adult; Aged; Blood Glucose; C-Reactive Protein - metabolism; Cell Adhesion; Cholesterol - blood; diabetes; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 2 - immunology; Female; Glucose - pharmacology; growth factors; Humans; inflammation; Intercellular Signaling Peptides and Proteins - secretion; macrophage; Macrophage Activation - drug effects; Macrophages - cytology; Macrophages - secretion; Macrophages - ultrastructure; Male; Middle Aged; Monocytes - cytology; Monocytes - secretion; Monocytes - ultrastructure; Platelet-Derived Growth Factor - metabolism; Proto-Oncogene Proteins c-sis; Stainless Steel; stent; Stents

In stent restenosis (ISR) has been described as an unaccomplished tissue healing and its rate is particularly high in diabetic patients. Evidence has been collected which relates the formation of ISR proteoglycan‐rich neointimal tissue to the accumulation and protracted activation of macrophages aro...