Mendelian Randomization Focused Analysis of Vitamin D on the Secondary Prevention of Ischemic Stroke

• Published in: Stroke (1970) Vol. 52; no. 12; pp. 3926 - 3937
• Main Authors: Chan, Yap-Hang, Schooling, C. Mary, Zhao, Jie, Au Yeung, Shiu-Lun, Hai, Jo Jo, Thomas, G. Neil, Cheng, Kar-Keung, Jiang, Chao-Qiang, Wong, Yuen-Kwun, Au, Ka-Wing, Tang, Clara S., Cheung, Chloe Y.Y., Xu, Aimin, Sham, Pak-Chung, Lam, Tai-Hing, Lam, Karen Siu-Ling, Tse, Hung-Fat
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.12.2021
• Subjects: Adult; Aged; Female; Genome-Wide Association Study; Genotype; Humans; Ischemic Stroke - blood; Ischemic Stroke - genetics; Male; Mendelian Randomization Analysis; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide; Secondary Prevention - methods; Vitamin D - blood; Vitamin D - genetics; recurrence; secondary prevention; vitamin D; ischemic stroke; myocardial infarction

Experimental studies showed vitamin D (Vit-D) could promote vascular regeneration and repair. Prior randomized studies had focused mainly on primary prevention. Whether Vit-D protects against ischemic stroke and myocardial infarction recurrence among subjects with prior ischemic insults was unknown....