Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy

• Published in: AIDS (London) Vol. 34; no. 4; pp. 513 - 518
• Main Authors: Angelovich, Thomas A, Trevillyan, Janine M, Hoy, Jennifer F, Wong, Michelle E, Agius, Paul A, Hearps, Anna C, Jaworowski, Anthony
• Format: Journal Article
• Language: English
• Published: England Copyright Wolters Kluwer Health, Inc 15.03.2020
• Subjects: Adult; Aged; AIDS/HIV; Antiretroviral Therapy, Highly Active; Atherosclerosis - etiology; Atherosclerosis - metabolism; Atherosclerosis - pathology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - metabolism; Carotid Intima-Media Thickness; Cross-Sectional Studies; Foam Cells - immunology; Foam Cells - metabolism; Foam Cells - pathology; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - virology; Humans; Inflammation - pathology; Linear Models; Male; Middle Aged; Monocytes - immunology; Monocytes - metabolism; Risk Factors

OBJECTIVE:People living with HIV have an increased risk of cardiovascular disease (CVD) despite effective antiretroviral therapy (ART). Monocytes play a key role in the early stages of atherosclerosis-driven CVD by forming lipid-laden foam cells within artery walls. HIV infection potentiates foam ce...