Free Choline, but Not Phosphatidylcholine, Elevates Circulating Trimethylamine-N-oxide and This Response Is Modified by the Gut Microbiota Composition in Healthy Men

• Published in: Current developments in nutrition Vol. 4; no. Supplement_2; p. nzaa045_012
• Main Authors: Cho, Clara, Aardema, Niklas DJ, Bunnell, Madison L, Larson, Deanna P, Aguilar, Sheryl S, Bergeson, Janet R, Malysheva, Olga V, Caudill, Marie A, Lefevre, Michael
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Inc 01.06.2020; Oxford University Press
• Subjects: Cardiovascular disease; Dietary Bioactive Components; Gastroenterology and Hepatology; Gut microbiota; Microbiota

Trimethylamine-N-oxide (TMAO), a choline-derived gut microbiota-dependent metabolite, is a newly recognized risk marker for cardiovascular disease. However, the contributions of different forms of choline and gut microbiota composition on TMAO production are largely unknown. The objectives of this s...