Preseizure increased gamma electroencephalographic activity has no effect on extracellular potassium or calcium

• Published in: Journal of neuroscience research Vol. 85; no. 4; pp. 906 - 918
• Main Authors: Broberg, Marita, Pope, Kenneth J., Nilsson, Michael, Wallace, Angus, Wilson, Jodie, Willoughby, John O.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2007
• Subjects: Analysis of Variance; Animals; astrocytes; astroglial cells; Brain - drug effects; Brain - physiopathology; Calcium - metabolism; cerebral-cortex; dentate gyrus; Dose-Response Relationship, Drug; Electroencephalography - drug effects; Epilepsy - chemically induced; Epilepsy - metabolism; Epilepsy - physiopathology; Extracellular Fluid - drug effects; Extracellular Fluid - metabolism; glial-cell metabolism; hippocampal astrocytes; homeostasis; in-vivo; induced limbic seizures; ion channels; ions; Kainic Acid - administration & dosage; Male; Neurosciences; Neurovetenskaper; Picrotoxin - administration & dosage; Potassium - metabolism; rat-brain; Rats; Rats, Sprague-Dawley; seizure; Spectrum Analysis; spreading depression

Extracellular ion concentrations change during seizures in seizure models. [K+]o increases and [Ca2+]o decreases, resulting from population discharges, enhanced neuronal excitability, though not obviously before seizure onset. In acute pharmacological epilepsy models, there are striking increases in...