The STROGHAT study protocol: An intervention study to evaluate safety, effectiveness and feasibility of treating gambiense HAT seropositive subjects with acoziborole

• Published in: Open research Europe Vol. 5; p. 23
• Main Authors: Nicco, Elena, Lejon, Veerle, Mwamba Miaka, Erick, Mumba, Dieudonné, Mpanya, Alain, Kambo, Charles, Ngolo, Digas, Mutombo, Wilfried, Hugonnet, Stéphane, Rembry, Sandra, Tipple, Craig, Inocencio Da Luz, Raquel, Snijders, Rian, Vander Kelen, Catiane, Rogé, Stijn, Van Reet, Nick, Tarral, Antoine, Verlé, Paul, Hasker, Epco
• Format: Journal Article
• Language: English
• Published: Belgium F1000 Research Limited 2025; F1000 Research Ltd
• Subjects: Acoziborole; Democratic Republic of Congo; Elimination; eng; Human African Trypanosomiasis; Study Protocol; Acoziborole; Human African Trypanosomiasis; Democratic Republic of Congo; Elimination

Background Coordinated efforts in the control of gambiense human African trypanosomiasis (gHAT) have significantly reduced its endemicity. WHO targets interruption of transmission by 2030. However, challenges remain, including low sensitivity of the current parasitological confirmation tests, leavin...