Combining SARS‐CoV‐2 interferon‐gamma release assay with humoral response assessment to define immune memory profiles

• Published in: European journal of immunology Vol. 54; no. 7; pp. e2451035 - n/a
• Main Authors: Mouton, William, Oriol, Guy, Compagnon, Christelle, Saade, Carla, Saker, Kahina, Franc, Priscille, Mokdad, Bouchra, Fleurie, Aurore, Lacoux, Xavier, Daniel, Soizic, Berthier, Franck, Barnel, Cécile, Pozzetto, Bruno, Fassier, Jean‐Baptiste, Dubois, Valérie, Djebali, Sophia, Dubois, Maxence, Walzer, Thierry, Marvel, Jacqueline, Brengel‐Pesce, Karen, Trouillet‐Assant, Sophie
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2024; Wiley-VCH Verlag
• Subjects: Adaptive immunity; Adult; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antiviral drugs; Cell-mediated immunity; COVID-19 - immunology; COVID-19 Vaccines - immunology; Female; Health Personnel; Humans; Humoral immunity; Immune memory profile; Immune response (humoral); Immunity, Humoral - immunology; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunologic Memory - immunology; Immunological memory; Immunology; Infections; Interferon; Interferon-gamma - immunology; Interferon-gamma - metabolism; Interferon-gamma Release Tests - methods; Interferon‐gamma release assay; Life Sciences; Male; Medical personnel; Middle Aged; Prophylaxis; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; Vaccination; Immune memory profile; Cell‐mediated immunity; Interferon‐gamma release assay

Objectives In the post‐SARS‐CoV‐2 pandemic era, “breakthrough infections” are still documented, due to variants of concerns (VoCs) emergence and waning humoral immunity. Despite widespread utilization, the definition of the anti‐Spike (S) immunoglobulin‐G (IgG) threshold to define protection has unv...