Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation

• Published in: British journal of cancer Vol. 116; no. 1; pp. 21 - 27
• Main Authors: Treister, Nathaniel, Nieder, Michael, Baggott, Christina, Olson, Ellen, Chen, Lu, Dang, Ha, Krailo, Mark, August, Amanda, Sung, Lillian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.01.2017; Nature Publishing Group
• Subjects: 631/92/436/108; 692/699/3020/3025; 692/699/67/2332; 692/700/565/545/576/1955; Adolescent; Adult; Biomedical and Life Sciences; Biomedicine; Calcium Phosphates - therapeutic use; Cancer; Cancer Research; Child; Child, Preschool; Clinical Study; Clinical trials; Drug dosages; Drug Resistance; Epidemiology; FDA approval; Female; Hematopoietic Stem Cell Transplantation - adverse effects; Hospitals; Humans; Hypertonic Solutions - therapeutic use; Male; Medicine; Molecular Medicine; Morphine; Mucositis; Myeloablative Agonists - therapeutic use; Oncology; Pediatrics; Prevention; Stomatitis - etiology; Stomatitis - prevention & control; Teenagers; Transplantation Conditioning - adverse effects; Transplantation Conditioning - methods; Transplantation, Homologous; Transplants & implants; Treatment Outcome; Young Adult; Atlanta Georgia; United States > US; oral mucositis; hematopoietic cell transplantation; pediatrics

Background: The primary objective was to determine whether topically administered Caphosol, rinsed orally four times daily at the initiation of conditioning, reduces the duration of severe oral mucositis (OM) compared with placebo among children and adolescents undergoing haematopoietic cell transpl...