Prostate cancer: germline prediction for a commonly variable malignancy

• Published in: BJU international Vol. 110; no. 11c; pp. E809 - E818
• Main Authors: Bambury, Richard M., Gallagher, David J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Wiley Subscription Services, Inc
• Subjects: Biomarkers; Clinical trials; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study - methods; Genomes; Germ-Line Mutation; germline genetics; Global Health; Humans; Incidence; Male; molecular biology; Mutation; Prostate cancer; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology

What's known on the subject? and What does the study add? Prostate cancer is a heterogeneous disease and biomarkers to predict its incidence and subsequent clinical behaviour are needed to tailor screening, prevention and therapeutic strategies. Rare mutations in genes such as BRCA1, BRCA2 and...