Functional and antigenic analyses of the 1918 influenza virus haemagglutinin using a recombinant vaccinia virus expression system

• Published in: Virus research Vol. 122; no. 1; pp. 11 - 19
• Main Authors: Elliot, Alex J., Steinhauer, David A., Daniels, Rod S., Oxford, John S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2006
• Subjects: 1918 Pandemic; Amino Acid Sequence; Animals; Antigens, Viral - immunology; Antigens, Viral - physiology; Cell Line; Gene Expression; Genetic Vectors; Haemagglutinin; Haplorhini; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinin Glycoproteins, Influenza Virus - physiology; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza virus; Molecular Sequence Data; Pathogenicity; Protein expression; Recombinant vaccinia virus; Vaccinia virus; Vaccinia virus - genetics; Virulence Factors - immunology; Virulence Factors - physiology; Virus Attachment; Virus Internalization; Pathogenicity; Protein expression; Recombinant vaccinia virus; Haemagglutinin; Influenza virus; 1918 Pandemic

The influenza pandemic of 1918 caused unprecedented levels of morbidity and mortality in its 12-month period of circulation around the globe. The haemagglutinin molecule has been shown to affect the pathogenicity of some subtypes of influenza A viruses. Using a recombinant vaccinia system that allow...