Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 67; no. 2; pp. 374 - 384
• Main Authors: Coşkun, Abdurrahman, Sandberg, Sverre, Unsal, Ibrahim, Cavusoglu, Coskun, Serteser, Mustafa, Kilercik, Meltem, Aarsand, Aasne K
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 30.01.2021; American Association for Clinical Chemistry, Inc
• Subjects: Biological variation; Customization; Estimates; Hematology; Intervals; Laboratories; Laboratory tests; Patients; Precision medicine; Steady state; Variation; Norway; biological variation; reference interval; analytical variation

Abstract Background The concept of personalized medicine has received widespread attention in the last decade. However, personalized medicine depends on correct diagnosis and monitoring of patients, for which personalized reference intervals for laboratory tests may be beneficial. In this study, we...