Nocturnal Hypoxemia Severity and Renin–Angiotensin System Activity in Obstructive Sleep Apnea

• Published in: American journal of respiratory and critical care medicine Vol. 192; no. 7; pp. 873 - 880
• Main Authors: Zalucky, Ann A., Nicholl, David D. M., Hanly, Patrick J., Poulin, Marc J., Turin, Tanvir C., Walji, Shahebina, Handley, George B., Raneri, Jill K., Sola, Darlene Y., Ahmed, Sofia B.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.10.2015
• Subjects: Adolescent; Adult; Aged; Comorbidity; Female; Hemodynamics; Humans; Hypoxia - epidemiology; Hypoxia - physiopathology; Kidney - blood supply; Kidney - physiopathology; Male; Middle Aged; Obesity - epidemiology; Regional Blood Flow; Renin-Angiotensin System - physiology; Sleep Apnea, Obstructive - epidemiology; Sleep Apnea, Obstructive - physiopathology; Young Adult; obstructive sleep apnea; angiotensin; hypoxemia; kidney; hemodynamics

Obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with chronic kidney disease and up-regulation of the renin-angiotensin system (RAS), which is deleterious to renal function. The extent to which the magnitude of RAS activation is influenced by the severity of nocturnal hypoxemia a...