Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

• Published in: Circulation (New York, N.Y.) Vol. 119; no. 9; pp. 1284 - 1292
• Main Authors: Pierce, Gary L., Lesniewski, Lisa A., Lawson, Brooke R., Beske, Stacy D., Seals, Douglas R.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 10.03.2009
• Subjects: Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fundamental and applied biological sciences. Psychology; Medical sciences; Vertebrates: cardiovascular system; Human; Obesity; Oxidative stress; Senescence; Nutrition disorder; Brachial artery; Cardiovascular disease; Inflammation; Endothelium; Overweight; Endothelial dysfunction; aging; Nutritional status

Background— We tested the hypothesis that nuclear factor-κB (NF-κB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans. Methods and Results— We conducted a randomized, double-blind, placebo-controlled crossover study in 14 nondiabetic overweight or obese (body...