Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI)

• Published in: American journal of physiology. Renal physiology Vol. 301; no. 4; pp. F697 - F707
• Main Authors: Endre, Zoltán H., Pickering, John W., Walker, Robert J.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2011
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - urine; Biomarkers; Biomarkers - blood; Biomarkers - urine; Creatinine - blood; Early Diagnosis; Glomerular Filtration Rate - physiology; Humans; Kidney diseases; Nephrology; Physiology

Acute kidney injury (AKI) is a common and frequently fatal illness in critically ill patients. The reliance on daily measurements of serum creatinine as a surrogate of glomerular filtration rate (GFR) not only delays diagnosis and development of successful therapies but also hinders insight into the...