Bite-size introduction to canine hematologic malignancies

Abstract Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most frequently encountered hematologic tumors in dogs include lymphoma, lymphoid and myeloid leukemias, and mast cell, plasma cell, and histiocyt...

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Published inBlood advances Vol. 6; no. 13; pp. 4073 - 4084
Main Authors Atherton, Matthew J., Mason, Nicola J.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society of Hematology 12.07.2022
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Abstract Abstract Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most frequently encountered hematologic tumors in dogs include lymphoma, lymphoid and myeloid leukemias, and mast cell, plasma cell, and histiocytic neoplasias. Coupled with the heterogeneous presentations of the different categories and subtypes of canine hematologic malignancies, outcomes for these tumors are also variable. Considering this, appropriate treatment options range from active surveillance to curative intent approaches harnessing surgical, chemotherapeutic, and radiation-based modalities. The underlying pathology of many of these diseases bears remarkable resemblance to that of the corresponding diagnosis made in human patients. We introduce some of the pathogenic drivers of canine hematologic cancers alongside their clinical presentations. An overview of standard-of-care therapies for each of these diseases is also provided. As comparative oncology gains recognition as a valuable setting in which to investigate the pathogenesis of neoplasia and provide powerful, clinically relevant, immunocompetent models for the evaluation of novel therapies, the number of clinicians and scientists participating in cancer research involving dogs is expected to increase. This review aims at providing an introductory overview of canine hematologic malignancies.
AbstractList Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most frequently encountered hematologic tumors in dogs include lymphoma, lymphoid and myeloid leukemias, and mast cell, plasma cell, and histiocytic neoplasias. Coupled with the heterogeneous presentations of the different categories and subtypes of canine hematologic malignancies, outcomes for these tumors are also variable. Considering this, appropriate treatment options range from active surveillance to curative intent approaches harnessing surgical, chemotherapeutic, and radiation-based modalities. The underlying pathology of many of these diseases bears remarkable resemblance to that of the corresponding diagnosis made in human patients. We introduce some of the pathogenic drivers of canine hematologic cancers alongside their clinical presentations. An overview of standard-of-care therapies for each of these diseases is also provided. As comparative oncology gains recognition as a valuable setting in which to investigate the pathogenesis of neoplasia and provide powerful, clinically relevant, immunocompetent models for the evaluation of novel therapies, the number of clinicians and scientists participating in cancer research involving dogs is expected to increase. This review aims at providing an introductory overview of canine hematologic malignancies.
Abstract Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most frequently encountered hematologic tumors in dogs include lymphoma, lymphoid and myeloid leukemias, and mast cell, plasma cell, and histiocytic neoplasias. Coupled with the heterogeneous presentations of the different categories and subtypes of canine hematologic malignancies, outcomes for these tumors are also variable. Considering this, appropriate treatment options range from active surveillance to curative intent approaches harnessing surgical, chemotherapeutic, and radiation-based modalities. The underlying pathology of many of these diseases bears remarkable resemblance to that of the corresponding diagnosis made in human patients. We introduce some of the pathogenic drivers of canine hematologic cancers alongside their clinical presentations. An overview of standard-of-care therapies for each of these diseases is also provided. As comparative oncology gains recognition as a valuable setting in which to investigate the pathogenesis of neoplasia and provide powerful, clinically relevant, immunocompetent models for the evaluation of novel therapies, the number of clinicians and scientists participating in cancer research involving dogs is expected to increase. This review aims at providing an introductory overview of canine hematologic malignancies.
Author Atherton, Matthew J.
Mason, Nicola J.
AuthorAffiliation 2 Department of Biomedical Sciences, and
3 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA
1 Department of Clinical Sciences and Advanced Medicine
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  givenname: Nicola J.
  orcidid: 0000-0002-6149-4927
  surname: Mason
  fullname: Mason, Nicola J.
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Cites_doi 10.1186/s12917-018-1587-9
10.1111/jvim.15967
10.3389/fonc.2020.00023
10.1111/vco.12374
10.1111/j.1476-5829.2009.00186.x
10.1016/S0195-5616(03)00003-2
10.1111/j.1439-0442.1967.tb00235.x
10.1016/j.exphem.2008.09.005
10.1038/s41598-020-68470-9
10.1111/j.1939-1676.2009.0289.x
10.1111/j.1939-1676.2010.0640.x
10.1111/vco.12693
10.1111/vde.12147
10.7554/eLife.50740
10.1371/journal.pone.0191205
10.1111/jvim.14729
10.1007/s00262-021-03033-z
10.1111/jvim.12116
10.1182/blood-2016-09-731893
10.1354/vp.43-5-632
10.1177/0300985813478210
10.1177/0300985810386469
10.1111/jvim.15084
10.1002/ijc.32991
10.1111/vco.12251
10.1111/vco.12377
10.1007/s00580-003-0480-4
10.1177/0300985819900352
10.1111/vco.12012
10.1046/j.1439-0442.2002.00458.x
10.1126/scitranslmed.aaf0746
10.1111/jvim.12304
10.1016/j.immuni.2019.12.011
10.1111/vco.12460
10.1292/jvms.68.581
10.1016/S0165-2427(99)00051-3
10.1111/j.1939-1676.2011.0767.x
10.1158/1535-7163.MCT-17-1273
10.1186/s12864-020-06872-9
10.1371/journal.pgen.1004922
10.1177/0300985818823668
10.1111/vco.12440
10.1111/j.1939-165X.2011.00341.x
10.1111/j.1476-5829.2010.00230.x
10.1177/0300985813510413
10.1111/j.1939-1676.2002.tb02411.x
10.1177/0300985810379428
10.1111/j.1939-1676.2007.tb02937.x
10.1177/0300985812465325
10.1016/j.xpro.2021.100905
10.1111/jsap.12688
10.1177/030098588402100503
10.1038/mt.2016.146
10.1111/vco.12227
10.1158/1078-0432.CCR-08-1860
10.1111/jvim.12343
10.1177/0300985810387446
10.1111/jvim.13814
10.1111/j.1939-1676.2008.00132.x
10.5326/0380135
10.1371/journal.pone.0215154
10.1177/1040638719882045
10.1111/vco.12605
10.1177/1040638716689581
10.1111/vco.12343
10.2460/javma.1994.205.12.1722
10.1080/2162402X.2019.1676615
10.1111/j.1476-5829.2011.00317.x
10.1111/j.1476-5810.2003.00025.x
10.1016/j.jcpa.2014.07.003
10.1177/0300985811398251
10.1080/01652176.2016.1152633
10.1111/j.1939-165X.2008.00099.x
10.1111/vco.12252
10.2460/javma.243.10.1436
10.1002/vms3.201
10.3109/07357900009012210
10.1158/0008-5472.CAN-12-3546
10.1111/vco.12588
10.1354/vp.41-4-371
10.1016/j.vetimm.2015.11.003
10.1354/vp.42-4-468
10.1111/j.1476-5829.2009.00189.x
10.1186/1471-2407-11-201
10.1111/jvim.16341
10.1182/blood-2013-05-498329
10.1371/journal.pone.0072591
10.1016/j.tvjl.2003.10.009
10.1038/ncomms10460
10.1111/j.1939-165X.2008.00042.x
10.1111/j.1476-5829.2009.00190.x
10.1111/vco.12609
10.1111/vco.12337
10.1111/vcp.12503
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References Thomas (2022071215270991000_B28) 2017; 15
LeBlanc (2022071215270991000_B1) 2016; 8
Jubala (2022071215270991000_B12) 2005; 42
Atherton (2022071215270991000_B2) 2016; 169
Harris (2022071215270991000_B29) 2019; 17
Bennett (2022071215270991000_B47) 2017; 15
Hottendorf (2022071215270991000_B60) 1967; 14
Avery (2022071215270991000_B30) 2014; 28
Thamm (2022071215270991000_B69) 2006; 68
Willmann (2022071215270991000_B58) 2019; 17
Boostrom (2022071215270991000_B82) 2017; 31
Richards (2022071215270991000_B22) 2013; 73
Rotolo (2022071215270991000_B103) 2021; 2
London (2022071215270991000_B71) 2009; 15
Garrett (2022071215270991000_B67) 2014; 5
Ponce (2022071215270991000_B15) 2004; 167
Rao (2022071215270991000_B36) 2011; 25
Patnaik (2022071215270991000_B62) 1984; 21
Dagher (2022071215270991000_B77) 2019; 31
Benjamin (2022071215270991000_B40) 2021; 19
Valli (2022071215270991000_B17) 2011; 48
Tasca (2022071215270991000_B51) 2009; 38
Usher (2022071215270991000_B50) 2009; 37
Dewhirst (2022071215270991000_B78) 1977; 170
Marconato (2022071215270991000_B98) 2020; 18
Lenz (2022071215270991000_B90) 2022; 71
Comazzi (2022071215270991000_B53) 2011; 25
Fernández (2022071215270991000_B83) 2018; 32
Moore (2022071215270991000_B85) 2014; 51
Weishaar (2022071215270991000_B44) 2022; 36
Giraudel (2022071215270991000_B80) 2002; 38
Pierezan (2022071215270991000_B86) 2014; 151
Pratschke (2022071215270991000_B68) 2013; 243
Raskin (2022071215270991000_B9) 2015
London (2022071215270991000_B61) 2003; 33
Swerdlow (2022071215270991000_B16) 2008
O’Brien (2022071215270991000_B24) 2013; 27
Panjwani (2022071215270991000_B102) 2019; 9
Giannuzzi (2022071215270991000_B19) 2019; 14
Dervisis (2022071215270991000_B100) 2017; 15
Labadie (2022071215270991000_B33) 2020; 21
Mudaliar (2022071215270991000_B21) 2013; 8
Maina (2022071215270991000_B96) 2014; 25
Vernau (2022071215270991000_B48) 1999; 69
Bromberek (2022071215270991000_B52) 2016; 30
Moore (2022071215270991000_B81) 2021; 35
Hedan (2022071215270991000_B92) 2011; 11
Rebhun (2022071215270991000_B38) 2011; 9
Mizuno (2022071215270991000_B41) 2020; 10
Atherton (2022071215270991000_B75) 2017; 46
Valli (2022071215270991000_B18) 2013; 50
Avery (2022071215270991000_B46) 2020; 10
Ott (2022071215270991000_B27) 2013; 122
Hayward (2022071215270991000_B6) 2016; 7
Jagielski (2022071215270991000_B35) 2002; 49
Peterson (2022071215270991000_B55) 1982; 180
Owen (2022071215270991000_B34) 1980
Saba (2022071215270991000_B42) 2018; 16
Seelig (2022071215270991000_B14) 2014; 28
Matus (2022071215270991000_B84) 1986; 188
Brodsky (2022071215270991000_B39) 2009; 23
Thompson (2022071215270991000_B65) 2011; 48
Ruslander (2022071215270991000_B10) 1997; 11
Warland (2022071215270991000_B64) 2014; 12
Kiupel (2022071215270991000_B66) 2004; 41
Marino (2022071215270991000_B56) 2017; 29
Saba (2022071215270991000_B43) 2020; 18
Moore (2022071215270991000_B94) 2006; 43
Teske (2022071215270991000_B11) 1994; 205
Hegde (2022071215270991000_B104) 2020; 52
Isotani (2022071215270991000_B72) 2008; 22
Sternberg (2022071215270991000_B74) 2009; 104
Sadowski (2022071215270991000_B45) 2018; 14
Hédan (2022071215270991000_B91) 2020; 147
Skorupski (2022071215270991000_B99) 2007; 21
Rout (2022071215270991000_B54) 2018; 13
Jaillardon (2022071215270991000_B76) 2011; 40
Haran (2022071215270991000_B13) 2020; 57
Allison (2022071215270991000_B95) 2008; 37
Stein (2022071215270991000_B25) 2019; 56
Garrett (2022071215270991000_B37) 2002; 16
Skorupski (2022071215270991000_B97) 2009; 7
Davis (2022071215270991000_B49) 2018; 16
Tonomura (2022071215270991000_B7) 2015; 11
Adam (2022071215270991000_B57) 2009; 7
Giannuzzi (2022071215270991000_B26) 2020; 18
Flood-Knapik (2022071215270991000_B8) 2013; 11
Sternberg (2022071215270991000_B79) 2009; 104
Ramos-Vara (2022071215270991000_B89) 2011; 48
Frantz (2022071215270991000_B20) 2013; 50
Valent (2022071215270991000_B73) 2017; 129
Fulmer (2022071215270991000_B87) 2007; 48
Cooper (2022071215270991000_B70) 2009; 7
Takada (2022071215270991000_B93) 2018; 17
Lenz (2022071215270991000_B88) 2017; 58
Hughes (2022071215270991000_B32) 2018; 16
Kiupel (2022071215270991000_B63) 2011; 48
Edwards (2022071215270991000_B4) 2003; 1
Panjwani (2022071215270991000_B101) 2016; 24
Ponce (2022071215270991000_B31) 2003; 12
Zandvliet (2022071215270991000_B5) 2016; 36
Guerin (2022071215270991000_B105) 2020; 9
Cozzi (2022071215270991000_B23) 2018; 16
Vail (2022071215270991000_B3) 2000; 18
Tamlin (2022071215270991000_B59) 2020; 6
References_xml – volume: 14
  start-page: 250
  issue: 1
  year: 2018
  ident: 2022071215270991000_B45
  article-title: Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma
  publication-title: BMC Vet Res.
  doi: 10.1186/s12917-018-1587-9
  contributor:
    fullname: Sadowski
– volume: 35
  start-page: 442
  issue: 1
  year: 2021
  ident: 2022071215270991000_B81
  article-title: Retrospective evaluation of the use of the International Myeloma Working Group response criteria in dogs with secretory multiple myeloma
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.15967
  contributor:
    fullname: Moore
– volume: 10
  start-page: 23
  year: 2020
  ident: 2022071215270991000_B46
  article-title: The genetic and molecular basis for canine models of human leukemia and lymphoma
  publication-title: Front Oncol.
  doi: 10.3389/fonc.2020.00023
  contributor:
    fullname: Avery
– volume: 16
  start-page: 246
  issue: 2
  year: 2018
  ident: 2022071215270991000_B23
  article-title: Canine nodal marginal zone lymphoma: descriptive insight into the biological behaviour
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12374
  contributor:
    fullname: Cozzi
– volume: 7
  start-page: 139
  issue: 2
  year: 2009
  ident: 2022071215270991000_B97
  article-title: Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5829.2009.00186.x
  contributor:
    fullname: Skorupski
– volume: 33
  start-page: 473
  issue: 3
  year: 2003
  ident: 2022071215270991000_B61
  article-title: Mast cell tumors in the dog
  publication-title: Vet Clin North Am Small Anim Pract.
  doi: 10.1016/S0195-5616(03)00003-2
  contributor:
    fullname: London
– volume: 14
  start-page: 272
  issue: 3
  year: 1967
  ident: 2022071215270991000_B60
  article-title: Pathologic survey of 300 extirpated canine mastocytomas
  publication-title: Zentralbl Veterinärmed A.
  doi: 10.1111/j.1439-0442.1967.tb00235.x
  contributor:
    fullname: Hottendorf
– volume: 180
  start-page: 415
  issue: 4
  year: 1982
  ident: 2022071215270991000_B55
  article-title: Diagnosis of canine primary polycythemia and management with hydroxyurea
  publication-title: J Am Vet Med Assoc.
  contributor:
    fullname: Peterson
– volume: 37
  start-page: 65
  issue: 1
  year: 2009
  ident: 2022071215270991000_B50
  article-title: RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias
  publication-title: Exp Hematol.
  doi: 10.1016/j.exphem.2008.09.005
  contributor:
    fullname: Usher
– volume: 10
  start-page: 11476
  issue: 1
  year: 2020
  ident: 2022071215270991000_B41
  article-title: Generation of a canine anti-canine CD20 antibody for canine lymphoma treatment
  publication-title: Sci Rep.
  doi: 10.1038/s41598-020-68470-9
  contributor:
    fullname: Mizuno
– volume: 23
  start-page: 578
  issue: 3
  year: 2009
  ident: 2022071215270991000_B39
  article-title: Asparaginase and MOPP treatment of dogs with lymphoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2009.0289.x
  contributor:
    fullname: Brodsky
– volume: 25
  start-page: 100
  issue: 1
  year: 2011
  ident: 2022071215270991000_B53
  article-title: Immunophenotype predicts survival time in dogs with chronic lymphocytic leukemia
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2010.0640.x
  contributor:
    fullname: Comazzi
– volume: 19
  start-page: 541
  issue: 3
  year: 2021
  ident: 2022071215270991000_B40
  article-title: Response-based modification of CHOP chemotherapy for canine B-cell lymphoma
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12693
  contributor:
    fullname: Benjamin
– volume: 25
  start-page: 559
  issue: 6
  year: 2014
  ident: 2022071215270991000_B96
  article-title: Multiple cutaneous histiocytomas treated with lomustine in a dog
  publication-title: Vet Dermatol.
  doi: 10.1111/vde.12147
  contributor:
    fullname: Maina
– volume: 9
  start-page: e50740
  year: 2020
  ident: 2022071215270991000_B105
  article-title: Preclinical murine tumor models: a structural and functional perspective
  publication-title: Elife.
  doi: 10.7554/eLife.50740
  contributor:
    fullname: Guerin
– volume: 13
  start-page: e0191205
  issue: 1
  year: 2018
  ident: 2022071215270991000_B54
  article-title: Preferential use of unmutated immunoglobulin heavy variable region genes in boxer dogs with chronic lymphocytic leukemia
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0191205
  contributor:
    fullname: Rout
– volume: 31
  start-page: 1074
  issue: 4
  year: 2017
  ident: 2022071215270991000_B82
  article-title: Canine cutaneous plasmacytosis: 21 cases (2005-2015)
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.14729
  contributor:
    fullname: Boostrom
– volume: 71
  start-page: 807
  issue: 4
  year: 2022
  ident: 2022071215270991000_B90
  article-title: Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma
  publication-title: Cancer Immunol Immunother.
  doi: 10.1007/s00262-021-03033-z
  contributor:
    fullname: Lenz
– volume: 27
  start-page: 949
  issue: 4
  year: 2013
  ident: 2022071215270991000_B24
  article-title: Clinical characteristics and outcome in dogs with splenic marginal zone lymphoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.12116
  contributor:
    fullname: O’Brien
– volume: 129
  start-page: 1420
  issue: 11
  year: 2017
  ident: 2022071215270991000_B73
  article-title: Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  publication-title: Blood.
  doi: 10.1182/blood-2016-09-731893
  contributor:
    fullname: Valent
– volume: 43
  start-page: 632
  issue: 5
  year: 2006
  ident: 2022071215270991000_B94
  article-title: Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages
  publication-title: Vet Pathol.
  doi: 10.1354/vp.43-5-632
  contributor:
    fullname: Moore
– volume: 50
  start-page: 738
  issue: 5
  year: 2013
  ident: 2022071215270991000_B18
  article-title: Canine lymphomas: association of classification type, disease stage, tumor subtype, mitotic rate, and treatment with survival
  publication-title: Vet Pathol.
  doi: 10.1177/0300985813478210
  contributor:
    fullname: Valli
– volume: 48
  start-page: 147
  issue: 1
  year: 2011
  ident: 2022071215270991000_B63
  article-title: Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior
  publication-title: Vet Pathol.
  doi: 10.1177/0300985810386469
  contributor:
    fullname: Kiupel
– volume: 32
  start-page: 1060
  issue: 3
  year: 2018
  ident: 2022071215270991000_B83
  article-title: Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.15084
  contributor:
    fullname: Fernández
– volume: 147
  start-page: 1657
  issue: 6
  year: 2020
  ident: 2022071215270991000_B91
  article-title: PTPN11 mutations in canine and human disseminated histiocytic sarcoma
  publication-title: Int J Cancer.
  doi: 10.1002/ijc.32991
  contributor:
    fullname: Hédan
– volume: 15
  start-page: 1101
  issue: 3
  year: 2017
  ident: 2022071215270991000_B47
  article-title: Canine acute leukaemia: 50 cases (1989-2014)
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12251
  contributor:
    fullname: Bennett
– volume: 16
  start-page: 268
  issue: 2
  year: 2018
  ident: 2022071215270991000_B49
  article-title: A retrospective review of acute myeloid leukaemia in 35 dogs diagnosed by a combination of morphologic findings, flow cytometric immunophenotyping and cytochemical staining results (2007-2015)
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12377
  contributor:
    fullname: Davis
– volume: 12
  start-page: 75
  issue: 2
  year: 2003
  ident: 2022071215270991000_B31
  article-title: Clinical, morphological and immunological study of 13 cases of canine lymphoblastic lymphoma: comparison with the human entity
  publication-title: Comp Clin Pathol.
  doi: 10.1007/s00580-003-0480-4
  contributor:
    fullname: Ponce
– volume: 57
  start-page: 241
  issue: 2
  year: 2020
  ident: 2022071215270991000_B13
  article-title: Generation and validation of an antibody to canine CD19 for diagnostic and future therapeutic purposes
  publication-title: Vet Pathol.
  doi: 10.1177/0300985819900352
  contributor:
    fullname: Haran
– volume: 12
  start-page: 287
  issue: 4
  year: 2014
  ident: 2022071215270991000_B64
  article-title: The utility of staging in canine mast cell tumours
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12012
  contributor:
    fullname: Warland
– volume: 49
  start-page: 419
  issue: 8
  year: 2002
  ident: 2022071215270991000_B35
  article-title: A retrospective study of the incidence and prognostic factors of multicentric lymphoma in dogs (1998-2000)
  publication-title: J Vet Med A Physiol Pathol Clin Med.
  doi: 10.1046/j.1439-0442.2002.00458.x
  contributor:
    fullname: Jagielski
– volume: 8
  start-page: 324ps5
  issue: 324
  year: 2016
  ident: 2022071215270991000_B1
  article-title: Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology
  publication-title: Sci Transl Med.
  doi: 10.1126/scitranslmed.aaf0746
  contributor:
    fullname: LeBlanc
– volume: 28
  start-page: 538
  issue: 2
  year: 2014
  ident: 2022071215270991000_B30
  article-title: Flow cytometric characterization and clinical outcome of CD4+ T-cell lymphoma in dogs: 67 cases
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.12304
  contributor:
    fullname: Avery
– volume: 5
  start-page: 49
  year: 2014
  ident: 2022071215270991000_B67
  article-title: Canine mast cell tumors: diagnosis, treatment, and prognosis
  publication-title: Vet Med (Auckl).
  contributor:
    fullname: Garrett
– volume: 104
  start-page: 468
  issue: 10
  year: 2009
  ident: 2022071215270991000_B74
  article-title: An overview of multiple myeloma in dogs and cats
  publication-title: Vet Med.
  contributor:
    fullname: Sternberg
– volume: 52
  start-page: 17
  issue: 1
  year: 2020
  ident: 2022071215270991000_B104
  article-title: Top 10 challenges in cancer immunotherapy
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2019.12.011
  contributor:
    fullname: Hegde
– volume: 17
  start-page: 253
  issue: 3
  year: 2019
  ident: 2022071215270991000_B29
  article-title: Canine CD4+ T-cell lymphoma identified by flow cytometry exhibits a consistent histomorphology and gene expression profile
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12460
  contributor:
    fullname: Harris
– volume: 68
  start-page: 581
  issue: 6
  year: 2006
  ident: 2022071215270991000_B69
  article-title: Outcome and prognostic factors following adjuvant prednisone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases
  publication-title: J Vet Med Sci.
  doi: 10.1292/jvms.68.581
  contributor:
    fullname: Thamm
– volume: 69
  start-page: 145
  issue: 2-4
  year: 1999
  ident: 2022071215270991000_B48
  article-title: An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction
  publication-title: Vet Immunol Immunopathol.
  doi: 10.1016/S0165-2427(99)00051-3
  contributor:
    fullname: Vernau
– volume: 25
  start-page: 1097
  issue: 5
  year: 2011
  ident: 2022071215270991000_B36
  article-title: Class II major histocompatibility complex expression and cell size independently predict survival in canine B-cell lymphoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2011.0767.x
  contributor:
    fullname: Rao
– volume: 17
  start-page: 2439
  issue: 11
  year: 2018
  ident: 2022071215270991000_B93
  article-title: Targeting MEK in a translational model of histiocytic sarcoma
  publication-title: Mol Cancer Ther.
  doi: 10.1158/1535-7163.MCT-17-1273
  contributor:
    fullname: Takada
– volume: 21
  start-page: 464
  issue: 1
  year: 2020
  ident: 2022071215270991000_B33
  article-title: Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors
  publication-title: BMC Genomics.
  doi: 10.1186/s12864-020-06872-9
  contributor:
    fullname: Labadie
– volume: 11
  start-page: e1004922
  issue: 2
  year: 2015
  ident: 2022071215270991000_B7
  article-title: Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004922
  contributor:
    fullname: Tonomura
– volume: 56
  start-page: 350
  issue: 3
  year: 2019
  ident: 2022071215270991000_B25
  article-title: Immunophenotypic characterization of canine splenic follicular-derived B-cell lymphoma
  publication-title: Vet Pathol.
  doi: 10.1177/0300985818823668
  contributor:
    fullname: Stein
– volume: 188
  start-page: 1288
  issue: 11
  year: 1986
  ident: 2022071215270991000_B84
  article-title: Prognostic factors for multiple myeloma in the dog
  publication-title: J Am Vet Med Assoc.
  contributor:
    fullname: Matus
– volume: 17
  start-page: 1
  issue: 1
  year: 2019
  ident: 2022071215270991000_B58
  article-title: Comparative oncology: the paradigmatic example of canine and human mast cell neoplasms
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12440
  contributor:
    fullname: Willmann
– volume: 40
  start-page: 351
  issue: 3
  year: 2011
  ident: 2022071215270991000_B76
  article-title: Waldenström’s macroglobulinemia in a dog with a bleeding diathesis
  publication-title: Vet Clin Pathol.
  doi: 10.1111/j.1939-165X.2011.00341.x
  contributor:
    fullname: Jaillardon
– volume: 9
  start-page: 38
  issue: 1
  year: 2011
  ident: 2022071215270991000_B38
  article-title: CHOP chemotherapy for the treatment of canine multicentric T-cell lymphoma
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5829.2010.00230.x
  contributor:
    fullname: Rebhun
– volume: 51
  start-page: 167
  issue: 1
  year: 2014
  ident: 2022071215270991000_B85
  article-title: A review of histiocytic diseases of dogs and cats
  publication-title: Vet Pathol.
  doi: 10.1177/0300985813510413
  contributor:
    fullname: Moore
– volume: 16
  start-page: 704
  issue: 6
  year: 2002
  ident: 2022071215270991000_B37
  article-title: Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2002.tb02411.x
  contributor:
    fullname: Garrett
– volume: 48
  start-page: 198
  issue: 1
  year: 2011
  ident: 2022071215270991000_B17
  article-title: Classification of canine malignant lymphomas according to the World Health Organization criteria
  publication-title: Vet Pathol.
  doi: 10.1177/0300985810379428
  contributor:
    fullname: Valli
– volume: 21
  start-page: 121
  issue: 1
  year: 2007
  ident: 2022071215270991000_B99
  article-title: CCNU for the treatment of dogs with histiocytic sarcoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2007.tb02937.x
  contributor:
    fullname: Skorupski
– volume: 50
  start-page: 693
  issue: 4
  year: 2013
  ident: 2022071215270991000_B20
  article-title: Molecular profiling reveals prognostically significant subtypes of canine lymphoma
  publication-title: Vet Pathol.
  doi: 10.1177/0300985812465325
  contributor:
    fullname: Frantz
– volume: 104
  start-page: 477
  issue: 10
  year: 2009
  ident: 2022071215270991000_B79
  article-title: Extramedullary and solitary osseous plasmacytomas in dogs and cats
  publication-title: Vet Med.
  contributor:
    fullname: Sternberg
– volume: 2
  start-page: 100905
  issue: 4
  year: 2021
  ident: 2022071215270991000_B103
  article-title: Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer
  publication-title: STAR Protoc.
  doi: 10.1016/j.xpro.2021.100905
  contributor:
    fullname: Rotolo
– volume: 58
  start-page: 461
  issue: 8
  year: 2017
  ident: 2022071215270991000_B88
  article-title: Histiocytic sarcoma in 14 miniature schnauzers – a new breed predisposition?
  publication-title: J Small Anim Pract.
  doi: 10.1111/jsap.12688
  contributor:
    fullname: Lenz
– volume: 21
  start-page: 469
  issue: 5
  year: 1984
  ident: 2022071215270991000_B62
  article-title: Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs
  publication-title: Vet Pathol.
  doi: 10.1177/030098588402100503
  contributor:
    fullname: Patnaik
– volume: 24
  start-page: 1602
  issue: 9
  year: 2016
  ident: 2022071215270991000_B101
  article-title: Feasibility and safety of RNA-transfected CD20-specific chimeric antigen receptor T cells in dogs with spontaneous B cell lymphoma
  publication-title: Mol Ther.
  doi: 10.1038/mt.2016.146
  contributor:
    fullname: Panjwani
– volume: 48
  start-page: 1041
  issue: 10
  year: 2007
  ident: 2022071215270991000_B87
  article-title: Canine histiocytic neoplasia: an overview
  publication-title: Can Vet J.
  contributor:
    fullname: Fulmer
– volume: 170
  start-page: 1313
  issue: 11
  year: 1977
  ident: 2022071215270991000_B78
  article-title: Idiopathic monoclonal (IgA) gammopathy in a dog
  publication-title: J Am Vet Med Assoc.
  contributor:
    fullname: Dewhirst
– volume: 15
  start-page: 852
  issue: 3
  year: 2017
  ident: 2022071215270991000_B28
  article-title: Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12227
  contributor:
    fullname: Thomas
– volume: 15
  start-page: 3856
  issue: 11
  year: 2009
  ident: 2022071215270991000_B71
  article-title: Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision
  publication-title: Clin Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-1860
  contributor:
    fullname: London
– volume: 28
  start-page: 878
  issue: 3
  year: 2014
  ident: 2022071215270991000_B14
  article-title: Canine T-zone lymphoma: unique immunophenotypic features, outcome, and population characteristics
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.12343
  contributor:
    fullname: Seelig
– volume: 48
  start-page: 156
  issue: 1
  year: 2011
  ident: 2022071215270991000_B65
  article-title: Canine subcutaneous mast cell tumor: characterization and prognostic indices
  publication-title: Vet Pathol.
  doi: 10.1177/0300985810387446
  contributor:
    fullname: Thompson
– volume: 30
  start-page: 215
  issue: 1
  year: 2016
  ident: 2022071215270991000_B52
  article-title: Breed distribution and clinical characteristics of B cell chronic lymphocytic leukemia in dogs
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.13814
  contributor:
    fullname: Bromberek
– volume: 22
  start-page: 985
  issue: 4
  year: 2008
  ident: 2022071215270991000_B72
  article-title: Effect of tyrosine kinase inhibition by imatinib mesylate on mast cell tumors in dogs
  publication-title: J Vet Intern Med.
  doi: 10.1111/j.1939-1676.2008.00132.x
  contributor:
    fullname: Isotani
– volume: 38
  start-page: 135
  issue: 2
  year: 2002
  ident: 2022071215270991000_B80
  article-title: Monoclonal gammopathies in the dog: a retrospective study of 18 cases (1986-1999) and literature review
  publication-title: J Am Anim Hosp Assoc.
  doi: 10.5326/0380135
  contributor:
    fullname: Giraudel
– volume: 14
  start-page: e0215154
  issue: 4
  year: 2019
  ident: 2022071215270991000_B19
  article-title: Mutational landscape of canine B-cell lymphoma profiled at single nucleotide resolution by RNA-seq
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0215154
  contributor:
    fullname: Giannuzzi
– volume: 31
  start-page: 868
  issue: 6
  year: 2019
  ident: 2022071215270991000_B77
  article-title: Plasma cell leukemia with plasmablastic morphology in a dog
  publication-title: J Vet Diagn Invest.
  doi: 10.1177/1040638719882045
  contributor:
    fullname: Dagher
– volume: 18
  start-page: 763
  issue: 4
  year: 2020
  ident: 2022071215270991000_B43
  article-title: Rabacfosadine for naïve canine intermediate to large cell lymphoma: efficacy and adverse event profile across three prospective clinical trials
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12605
  contributor:
    fullname: Saba
– volume: 29
  start-page: 338
  issue: 3
  year: 2017
  ident: 2022071215270991000_B56
  article-title: Atypical chronic myeloid leukemia in a German shepherd dog
  publication-title: J Vet Diagn Invest.
  doi: 10.1177/1040638716689581
  contributor:
    fullname: Marino
– volume: 11
  start-page: 169
  issue: 2
  year: 1997
  ident: 2022071215270991000_B10
  article-title: Immunophenotypic characterization of canine lymphoproliferative disorders
  publication-title: In Vivo.
  contributor:
    fullname: Ruslander
– year: 2008
  ident: 2022071215270991000_B16
  contributor:
    fullname: Swerdlow
– year: 2015
  ident: 2022071215270991000_B9
  contributor:
    fullname: Raskin
– volume: 16
  start-page: E109
  issue: 1
  year: 2018
  ident: 2022071215270991000_B32
  article-title: Increased frequency of CD45 negative T cells (T zone cells) in older golden retriever dogs
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12343
  contributor:
    fullname: Hughes
– volume: 205
  start-page: 1722
  issue: 12
  year: 1994
  ident: 2022071215270991000_B11
  article-title: Prognostic factors for treatment of malignant lymphoma in dogs
  publication-title: J Am Vet Med Assoc.
  doi: 10.2460/javma.1994.205.12.1722
  contributor:
    fullname: Teske
– volume: 9
  start-page: 1676615
  issue: 1
  year: 2019
  ident: 2022071215270991000_B102
  article-title: Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma
  publication-title: Oncoimmunology.
  doi: 10.1080/2162402X.2019.1676615
  contributor:
    fullname: Panjwani
– volume: 11
  start-page: 272
  issue: 4
  year: 2013
  ident: 2022071215270991000_B8
  article-title: Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5829.2011.00317.x
  contributor:
    fullname: Flood-Knapik
– volume: 1
  start-page: 200
  issue: 4
  year: 2003
  ident: 2022071215270991000_B4
  article-title: Breed incidence of lymphoma in a UK population of insured dogs
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5810.2003.00025.x
  contributor:
    fullname: Edwards
– volume: 151
  start-page: 347
  issue: 4
  year: 2014
  ident: 2022071215270991000_B86
  article-title: Immunohistochemical expression of ionized calcium binding adapter molecule 1 in cutaneous histiocytic proliferative, neoplastic and inflammatory disorders of dogs and cats
  publication-title: J Comp Pathol.
  doi: 10.1016/j.jcpa.2014.07.003
  contributor:
    fullname: Pierezan
– volume: 48
  start-page: 758
  issue: 3
  year: 2011
  ident: 2022071215270991000_B89
  article-title: Immunohistochemical expression of E-cadherin does not distinguish canine cutaneous histiocytoma from other canine round cell tumors
  publication-title: Vet Pathol.
  doi: 10.1177/0300985811398251
  contributor:
    fullname: Ramos-Vara
– volume: 36
  start-page: 76
  issue: 2
  year: 2016
  ident: 2022071215270991000_B5
  article-title: Canine lymphoma: a review
  publication-title: Vet Q.
  doi: 10.1080/01652176.2016.1152633
  contributor:
    fullname: Zandvliet
– volume: 38
  start-page: 2
  issue: 1
  year: 2009
  ident: 2022071215270991000_B51
  article-title: Hematologic abnormalities and flow cytometric immunophenotyping results in dogs with hematopoietic neoplasia: 210 cases (2002-2006)
  publication-title: Vet Clin Pathol.
  doi: 10.1111/j.1939-165X.2008.00099.x
  contributor:
    fullname: Tasca
– volume: 15
  start-page: 1171
  issue: 4
  year: 2017
  ident: 2022071215270991000_B100
  article-title: Clinical prognostic factors in canine histiocytic sarcoma
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12252
  contributor:
    fullname: Dervisis
– volume: 243
  start-page: 1436
  issue: 10
  year: 2013
  ident: 2022071215270991000_B68
  article-title: Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (2008-2012)
  publication-title: J Am Vet Med Assoc.
  doi: 10.2460/javma.243.10.1436
  contributor:
    fullname: Pratschke
– volume: 6
  start-page: 3
  issue: 1
  year: 2020
  ident: 2022071215270991000_B59
  article-title: Comparative aspects of mast cell neoplasia in animals and the role of KIT in prognosis and treatment
  publication-title: Vet Med Sci.
  doi: 10.1002/vms3.201
  contributor:
    fullname: Tamlin
– volume: 18
  start-page: 781
  issue: 8
  year: 2000
  ident: 2022071215270991000_B3
  article-title: Spontaneously occurring tumors of companion animals as models for human cancer
  publication-title: Cancer Invest.
  doi: 10.3109/07357900009012210
  contributor:
    fullname: Vail
– volume: 73
  start-page: 5029
  issue: 16
  year: 2013
  ident: 2022071215270991000_B22
  article-title: Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-3546
  contributor:
    fullname: Richards
– volume: 18
  start-page: 645
  issue: 4
  year: 2020
  ident: 2022071215270991000_B26
  article-title: Integrated analysis of transcriptome, methylome and copy number aberrations data of marginal zone lymphoma and follicular lymphoma in dog
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12588
  contributor:
    fullname: Giannuzzi
– volume: 41
  start-page: 371
  issue: 4
  year: 2004
  ident: 2022071215270991000_B66
  article-title: The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors
  publication-title: Vet Pathol.
  doi: 10.1354/vp.41-4-371
  contributor:
    fullname: Kiupel
– volume: 169
  start-page: 15
  year: 2016
  ident: 2022071215270991000_B2
  article-title: Cancer immunology and canine malignant melanoma: a comparative review
  publication-title: Vet Immunol Immunopathol.
  doi: 10.1016/j.vetimm.2015.11.003
  contributor:
    fullname: Atherton
– volume: 42
  start-page: 468
  issue: 4
  year: 2005
  ident: 2022071215270991000_B12
  article-title: CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma
  publication-title: Vet Pathol.
  doi: 10.1354/vp.42-4-468
  contributor:
    fullname: Jubala
– volume: 7
  start-page: 181
  issue: 3
  year: 2009
  ident: 2022071215270991000_B57
  article-title: Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5829.2009.00189.x
  contributor:
    fullname: Adam
– volume: 11
  start-page: 201
  year: 2011
  ident: 2022071215270991000_B92
  article-title: Molecular cytogenetic characterization of canine histiocytic sarcoma: a spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
  publication-title: BMC Cancer.
  doi: 10.1186/1471-2407-11-201
  contributor:
    fullname: Hedan
– volume: 36
  start-page: 215
  issue: 1
  year: 2022
  ident: 2022071215270991000_B44
  article-title: Multicenter, randomized, double-blinded, placebo-controlled study of rabacfosadine in dogs with lymphoma
  publication-title: J Vet Intern Med.
  doi: 10.1111/jvim.16341
  contributor:
    fullname: Weishaar
– volume: 122
  start-page: 3884
  issue: 24
  year: 2013
  ident: 2022071215270991000_B27
  article-title: Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification
  publication-title: Blood.
  doi: 10.1182/blood-2013-05-498329
  contributor:
    fullname: Ott
– volume: 8
  start-page: e72591
  issue: 9
  year: 2013
  ident: 2022071215270991000_B21
  article-title: Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL)
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0072591
  contributor:
    fullname: Mudaliar
– volume: 167
  start-page: 158
  issue: 2
  year: 2004
  ident: 2022071215270991000_B15
  article-title: Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy
  publication-title: Vet J.
  doi: 10.1016/j.tvjl.2003.10.009
  contributor:
    fullname: Ponce
– volume: 7
  start-page: 10460
  year: 2016
  ident: 2022071215270991000_B6
  article-title: Complex disease and phenotype mapping in the domestic dog
  publication-title: Nat Commun.
  doi: 10.1038/ncomms10460
  contributor:
    fullname: Hayward
– volume: 37
  start-page: 190
  issue: 2
  year: 2008
  ident: 2022071215270991000_B95
  article-title: Dendritic cell leukemia in a golden retriever
  publication-title: Vet Clin Pathol.
  doi: 10.1111/j.1939-165X.2008.00042.x
  contributor:
    fullname: Allison
– volume: 7
  start-page: 196
  issue: 3
  year: 2009
  ident: 2022071215270991000_B70
  article-title: Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases
  publication-title: Vet Comp Oncol.
  doi: 10.1111/j.1476-5829.2009.00190.x
  contributor:
    fullname: Cooper
– volume: 18
  start-page: 778
  issue: 4
  year: 2020
  ident: 2022071215270991000_B98
  article-title: Outcome comparison between radiation therapy and surgery as primary treatment for dogs with periarticular histiocytic sarcoma: an Italian Society of Veterinary Oncology study
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12609
  contributor:
    fullname: Marconato
– volume: 16
  start-page: E76
  issue: 1
  year: 2018
  ident: 2022071215270991000_B42
  article-title: Rabacfosadine for relapsed canine B-cell lymphoma: efficacy and adverse event profiles of 2 different doses
  publication-title: Vet Comp Oncol.
  doi: 10.1111/vco.12337
  contributor:
    fullname: Saba
– volume: 46
  start-page: 520
  issue: 3
  year: 2017
  ident: 2022071215270991000_B75
  article-title: A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog
  publication-title: Vet Clin Pathol.
  doi: 10.1111/vcp.12503
  contributor:
    fullname: Atherton
– year: 1980
  ident: 2022071215270991000_B34
  contributor:
    fullname: Owen
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Snippet Abstract Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most...
Hematologic malignancies are frequently diagnosed in dogs and result in a spectrum of clinical signs associated with specific disease types. The most...
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SubjectTerms Review
Title Bite-size introduction to canine hematologic malignancies
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https://pubmed.ncbi.nlm.nih.gov/PMC9278293
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