Modulation of renal calcium handling by 11β-hydroxysteroid dehydrogenase type 2

• Published in: Journal of the American Society of Nephrology Vol. 13; no. 10; pp. 2540 - 2546
• Main Authors: FERRARI, Paolo, BIANCHETTI, Mario G, SANSONNENS, Aurelie, FREY, Felix J
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.10.2002
• Subjects: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adult; Biological and medical sciences; Blood Pressure - drug effects; Calcium - metabolism; Drug toxicity and drugs side effects treatment; Female; Glycyrrhetinic Acid - pharmacology; Humans; Hydroxysteroid Dehydrogenases - metabolism; Kidney - metabolism; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Pharmacology. Drug treatments; Potassium - blood; Prospective Studies; Tetrahydrocortisol - metabolism; Tetrahydrocortisone - metabolism; Endocrinopathy; Human; Adrenal cortex diseases; Enzyme; Steroid hormone; Hyperadrenocorticism; Glucocorticoid; In vivo; Conn syndrome; Calcium ion; Adrenal hormone; Adrenal gland diseases; 11β-Hydroxysteroid dehydrogenase; Complication; Serum; Oxidoreductases; Inhibition; Tubular reabsorption; Quantitative analysis

Reduced concentration of serum ionized calcium and increased urinary calcium excretion have been reported in primary aldosteronism and glucocorticoid-treated patients. A reduced activity of the 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD2) results in overstimulation of the mineralocorti...