Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that...
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| Published in | Journal of neuroimmunology Vol. 166; no. 1; pp. 173 - 179 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2005
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| Abstract | We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+
7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+
T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients. |
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| AbstractList | We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients. We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients. |
| Author | Silvia Della Bella Saresella, Marina Speciale, Livianna Ferrante, Pasquale Trabattoni, Daria Filippi, Massimo Fasano, Francesca Cavarretta, Rosella Caputo, Domenico Ruzzante, Stefania Clerici, Mario Marventano, Ivana |
| Author_xml | – sequence: 1 givenname: Marina surname: Saresella fullname: Saresella, Marina organization: Laboratory of Molecular Medicine and Biotechnology, IRCCS S.Maria Nascente, Don C. Gnocchi Foundation, Via Capecelatro, 66, Milan, Italy – sequence: 2 givenname: Ivana surname: Marventano fullname: Marventano, Ivana organization: Laboratory of Molecular Medicine and Biotechnology, IRCCS S.Maria Nascente, Don C. Gnocchi Foundation, Via Capecelatro, 66, Milan, Italy – sequence: 3 givenname: Livianna surname: Speciale fullname: Speciale, Livianna organization: Laboratory of Molecular Medicine and Biotechnology, IRCCS S.Maria Nascente, Don C. Gnocchi Foundation, Via Capecelatro, 66, Milan, Italy – sequence: 4 givenname: Stefania surname: Ruzzante fullname: Ruzzante, Stefania organization: Laboratory of Molecular Medicine and Biotechnology, IRCCS S.Maria Nascente, Don C. Gnocchi Foundation, Via Capecelatro, 66, Milan, Italy – sequence: 5 givenname: Daria surname: Trabattoni fullname: Trabattoni, Daria organization: Chair of Immunology, DISP LITA VIALBA, University of Milan, Via G.B. Grassi 74, Milan, Italy – sequence: 6 surname: Silvia Della Bella fullname: Silvia Della Bella organization: Department of Biomedical Sciences and Technologies, University of Milan Via Fratelli Cervi 15, Milan, Italy – sequence: 7 givenname: Massimo surname: Filippi fullname: Filippi, Massimo organization: Neuroimaging Research Unit, Ospedale San Raffaele, IRCCS, Via Olgettina 7, Milan, Italy – sequence: 8 givenname: Francesca surname: Fasano fullname: Fasano, Francesca organization: Chair of Immunology, DISP LITA VIALBA, University of Milan, Via G.B. Grassi 74, Milan, Italy – sequence: 9 givenname: Rosella surname: Cavarretta fullname: Cavarretta, Rosella organization: Multiple Sclerosis Unit, Don C. Gnocchi ONLUS Foundation, IRCCS, Via Capecelatro, 66, Milan, Italy – sequence: 10 givenname: Domenico surname: Caputo fullname: Caputo, Domenico organization: Multiple Sclerosis Unit, Don C. Gnocchi ONLUS Foundation, IRCCS, Via Capecelatro, 66, Milan, Italy – sequence: 11 givenname: Mario surname: Clerici fullname: Clerici, Mario organization: Chair of Immunology, DISP LITA VIALBA, University of Milan, Via G.B. Grassi 74, Milan, Italy – sequence: 12 givenname: Pasquale surname: Ferrante fullname: Ferrante, Pasquale email: pferrante@dongnocchi.it organization: Laboratory of Molecular Medicine and Biotechnology, IRCCS S.Maria Nascente, Don C. Gnocchi Foundation, Via Capecelatro, 66, Milan, Italy |
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| Keywords | Multiple sclerosis Immunology T lymphocyte Myelin basic protein Apoptosis |
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| Snippet | We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by... |
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| SubjectTerms | Acute Disease Adult Apoptosis Biomarkers - metabolism Case-Control Studies CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism fas Receptor - metabolism Female Humans Immunology Male Middle Aged Multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology Myelin basic protein Myelin Basic Protein - metabolism Myelin Basic Protein - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism T lymphocyte Tetradecanoylphorbol Acetate - pharmacology |
| Title | Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis |
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