Effect of luteinizing hormone on follicle stimulating hormone-activated paracrine signalling in rat ovary

• Published in: Human reproduction (Oxford) Vol. 10; no. 1; p. 33
• Main Authors: Smyth, C D, Miró, F, Howles, C M, Hillier, S G
• Format: Journal Article
• Language: English
• Published: England 01.01.1995
• Subjects: Aldehyde-Lyases - genetics; Androstenedione - biosynthesis; Animals; Aromatase - metabolism; Cytochrome P-450 Enzyme System - genetics; Drug Interactions; Female; Follicle Stimulating Hormone - administration & dosage; Granulosa Cells - drug effects; Granulosa Cells - enzymology; Hormones - blood; Humans; Luteinizing Hormone - administration & dosage; Organ Size - drug effects; Ovary - anatomy & histology; Ovary - drug effects; Ovary - metabolism; Rats; Rats, Wistar; Recombinant Proteins - administration & dosage; RNA, Messenger - genetics; RNA, Messenger - metabolism; Steroid 17-alpha-Hydroxylase; Theca Cells - drug effects; Theca Cells - metabolism; Uterus - anatomy & histology; Uterus - drug effects

'Pure' follicle stimulating hormone (FSH) and luteinizing hormone (LH) are expected shortly to become available for pharmaceutical use in the clinical setting. To test the contribution of LH to optimal ovarian responsiveness to FSH, 21-day-old hypophysectomized, immature, female rats recei...