Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A Randomized Trial

• Published in: American journal of respiratory and critical care medicine Vol. 199; no. 9; pp. 1097 - 1105
• Main Authors: Permpikul, Chairat, Tongyoo, Surat, Viarasilpa, Tanuwong, Trainarongsakul, Thavinee, Chakorn, Tipa, Udompanturak, Suthipol
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.05.2019
• Subjects: Aged; Catecholamines; Clinical trials; Critical care; Double-Blind Method; Female; Hemodynamics - drug effects; Hormones; Humans; Hypotension - drug therapy; Hypotension - etiology; Male; Middle Aged; Neurotransmitters; Norepinephrine - administration & dosage; Norepinephrine - therapeutic use; Resuscitation - methods; Sepsis; Shock, Septic - complications; Shock, Septic - drug therapy; Shock, Septic - therapy; Vasoconstrictor Agents - administration & dosage; Vasoconstrictor Agents - therapeutic use; norepinephrine; resuscitation; septic shock; sepsis with hypotension; early norepinephrine administration

Recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation; however, prospective data to support this assertion are scarce. To conduct a phase II trial evaluating the hypothesis that early low-dose norepinephrine in adults with sepsis with hypoten...