Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease

• Published in: Kidney international Vol. 64; no. 3; pp. 978 - 991
• Main Authors: Himmelfarb, Jonathan, Kane, Jane, Mcmonagle, Ellen, Zaltas, Eric, Bobzin, Steve, Boddupalli, Sekhar, Phinney, Stephen, Miller, Guy
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2003; Elsevier Limited
• Subjects: Acute-Phase Reaction - blood; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - blood; alpha-Tocopherol - metabolism; C-Reactive Protein - metabolism; Case-Control Studies; CEHC; Chromans - blood; CRP; Dose-Response Relationship, Drug; Drug Administration Schedule; ESRD; Female; gamma-Tocopherol - administration & dosage; gamma-Tocopherol - blood; gamma-Tocopherol - metabolism; Humans; Interleukin-6 - blood; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - therapy; Male; Middle Aged; oxidative stress; Renal Dialysis; tocopherol; ESRD; CRP; CEHC; tocopherol; oxidative stress

Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease. The metabolism of alpha and gamma tocopherol, the major components of vitamin E, have not been studied in uremic patients. The major pathway of tocopherol metabolism is via phytyl side chain oxidatio...