1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents

• Published in: Medicinal chemistry research Vol. 32; no. 1; pp. 158 - 164
• Main Authors: Seck, Insa, Ciss, Ismaïla, Diédhiou, Adama, Baldé, Mamadou, Ka, Seydou, Ba, Lalla A., Ndoye, Samba F., Figadère, Bruno, Seon-Meniel, Blandine, Gomez, Generosa, Cojean, Sandrine, Pomel, Sébastien, Loiseau, Philippe M., Fall, Yagamare, Seck, Matar
• Format: Journal Article
• Language: English
• Published: New York Springer US 2023; Springer Nature B.V; Springer Verlag
• Subjects: Antiparasitic agents; Antiprotozoal agents; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Chemical compounds; Chemical Sciences; Cholesterol; Drug resistance; Drugs; Germfree; Inorganic Chemistry; Leishmania donovani; Leishmaniasis; Life Sciences; Malaria; Medicinal Chemistry; Microbiology and Parasitology; Morbidity; Original Research; Parasitology; Pharmacology; Pharmacology/Toxicology; Plasmodium falciparum; Populations; Protozoa; Selectivity; Triazoles; Tropical diseases; Trypanosoma brucei gambiense; Trypanosomiasis; Antiparasitic activity; 1,2,3-triazene; Leishmaniasis; Malaria; Trypanosomiasis; 1,2,3-triazole; trypanosomiasis; antiparasitic activity; 1-2-3-triazole; leishmaniasis; malaria; 1-2-3-triazene

Trypanosomiasis, leishmaniasis, and malaria are tropical diseases that affect poor populations and the commonly-used drugs are toxic and can be subject to drug resistance. There is, therefore, an urgent need to find effective therapeutic agents accessible to these populations that bear the brunt of...