Effects of physical activity and age on mitochondrial function

• Published in: QJM : An International Journal of Medicine Vol. 89; no. 4; pp. 251 - 258
• Main Authors: Brierley, E.J., Johnson, M.A., James, O.F.W., Turnbull, D.M.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.1996
• Subjects: Adult; Aged; Aged, 80 and over; Aging - physiology; Biological and medical sciences; Cell structures and functions; DNA, Mitochondrial; Exercise - physiology; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Mitochondria and cell respiration; Mitochondria, Muscle - metabolism; Mitochondria, Muscle - physiology; Molecular and cellular biology; Muscles - enzymology; Mutation; Oxidative Stress; Space life sciences; Physical exercise; Human; Respiratory chain; Correlation; Mitochondria; Biological activity; Age

It has been proposed that ageing results from the accumulation of mitochondrial DNA mutations with age which interfere with respiratory chain ATP production. Insufficient ATP production impairs cell function, and tissue dysfunction ensues, leading to morbidity, decline and eventually death. Supporti...