Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology

• Published in: The Journal of infectious diseases Vol. 225; no. 3; pp. 404 - 412
• Main Authors: Ryan, Kathryn A, Schewe, Katarzyna E, Crowe, Jonathan, Fotheringham, Susan A, Hall, Yper, Humphreys, Richard, Marriott, Anthony C, Paterson, Jemma, Rayner, Emma, Salguero, Francisco J, Watson, Robert J, Whittaker, Catherine J, Carroll, Miles W, Dibben, Oliver
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.02.2022
• Subjects: Animals; Coronaviruses; COVID-19 - therapy; COVID-19 vaccines; Disease Models, Animal; Ferrets; Infections; Influenza; Influenza Vaccines - therapeutic use; Lung; Lung diseases; Pathology; Respiratory System - virology; Respiratory tract; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; Vaccines; Vaccines, Attenuated - therapeutic use; Virus Replication; Virus Shedding; COVID-19; live attenuated influenza vaccine; LAIV; SARS-CoV-2; coinfection; ferret

Abstract Cocirculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in coinfected patients. The initial lack of a readily available coronavi...